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1.
Prospective prediction of plasma pharmacokinetics of a novel immune-modulating agent in cancer patients after intra-tumoral administration: translation from non-clinical species to humans.
Xenobiotica
; 51(11): 1255-1263, 2021 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-34461800
2.
The effect of ABCG2 and ABCC4 on the pharmacokinetics of methotrexate in the brain.
Drug Metab Dispos
; 42(4): 537-40, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24464805
3.
Saturable active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier leads to nonlinear distribution of elacridar to the central nervous system.
J Pharmacol Exp Ther
; 345(1): 111-24, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23397054
4.
Impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on the brain distribution of a novel BRAF inhibitor: vemurafenib (PLX4032).
J Pharmacol Exp Ther
; 342(1): 33-40, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22454535
5.
Brain distribution and bioavailability of elacridar after different routes of administration in the mouse.
Drug Metab Dispos
; 40(8): 1612-9, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22611067
6.
Quantitative proteomics of transporter expression in brain capillary endothelial cells isolated from P-glycoprotein (P-gp), breast cancer resistance protein (Bcrp), and P-gp/Bcrp knockout mice.
Drug Metab Dispos
; 40(6): 1164-9, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22401960
7.
Discovery of BMS-986339, a Pharmacologically Differentiated Farnesoid X Receptor Agonist for the Treatment of Nonalcoholic Steatohepatitis.
J Med Chem
; 65(13): 8948-8960, 2022 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-35704802
8.
Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies.
Mol Ther Nucleic Acids
; 29: 625-642, 2022 Sep 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36090761
9.
Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain.
Expert Rev Mol Med
; 13: e17, 2011 May 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-21676290
10.
The role of the breast cancer resistance protein (ABCG2) in the distribution of sorafenib to the brain.
J Pharmacol Exp Ther
; 336(1): 223-33, 2011 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-20952483
11.
Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux.
J Pharmacol Exp Ther
; 334(1): 147-55, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20421331
12.
Development and evaluation of a novel microemulsion formulation of elacridar to improve its bioavailability.
J Pharm Sci
; 102(4): 1343-54, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23334925
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