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1.
Workshop Report: FDA Workshop on Improving Cardiotoxicity Assessment With Human-Relevant Platforms.
Circ Res
; 125(9): 855-867, 2019 10 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31600125
2.
Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay.
Toxicol Appl Pharmacol
; 390: 114883, 2020 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31981640
3.
Assessment of the clinical cardiac drug-drug interaction associated with the combination of hepatitis C virus nucleotide inhibitors and amiodarone in guinea pigs and rhesus monkeys.
Hepatology
; 64(5): 1430-1441, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27474787
4.
Interaction between amiodarone and hepatitis-C virus nucleotide inhibitors in human induced pluripotent stem cell-derived cardiomyocytes and HEK-293 Cav1.2 over-expressing cells.
Toxicol Appl Pharmacol
; 308: 66-76, 2016 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27520758
5.
Resolving the Reversed Rate Effect of Calcium Channel Blockers on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and the Impact on In Vitro Cardiac Safety Evaluation.
Toxicol Sci
; 167(2): 573-580, 2019 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30365015
6.
Human-induced pluripotent stem cell-derived cardiomyocytes have limited IKs for repolarization reserve as revealed by specific KCNQ1/KCNE1 blocker.
JRSM Cardiovasc Dis
; 8: 2048004019854919, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31217965
7.
HiPSC-CMs from different sex and ethnic origin donors exhibit qualitatively different responses to several classes of pharmacological challenges.
J Pharmacol Toxicol Methods
; 99: 106598, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31201864
8.
Cell culture conditions affect the ability of high content imaging assay to detect drug-induced changes in cellular parameters in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs).
Toxicol Rep
; 6: 305-320, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31011540
9.
Drug-induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias.
Br J Pharmacol
; 176(19): 3819-3833, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31271649
10.
Response of safety pharmacologists to challenges arising from the rapidly evolving changes in the pharmaceutical industry.
J Pharmacol Toxicol Methods
; 98: 106593, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31158459
11.
Assessing Drug-Induced Long QT and Proarrhythmic Risk Using Human Stem-Cell-Derived Cardiomyocytes in a Ca2+ Imaging Assay: Evaluation of 28 CiPA Compounds at Three Test Sites.
Toxicol Sci
; 170(2): 345-356, 2019 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31020317
12.
Response of human induced pluripotent stem cell-derived cardiomyocytes to several pharmacological agents when intrinsic syncytial pacing is overcome by acute external stimulation.
J Pharmacol Toxicol Methods
; 91: 18-26, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29330131
13.
Cardiac drug-drug interaction between HCV-NS5B pronucleotide inhibitors and amiodarone is determined by their specific diastereochemistry.
Sci Rep
; 7: 44820, 2017 03 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28327633
14.
Use of FDSS/µCell imaging platform for preclinical cardiac electrophysiology safety screening of compounds in human induced pluripotent stem cell-derived cardiomyocytes.
J Pharmacol Toxicol Methods
; 81: 217-22, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27222351
15.
Application of a systems pharmacology model for translational prediction of hERG-mediated QTc prolongation.
Pharmacol Res Perspect
; 4(6): e00270, 2016 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28097003
16.
Characterization of an investigative safety pharmacology model to assess comprehensive cardiac function and structure in chronically instrumented conscious beagle dogs.
J Pharmacol Toxicol Methods
; 81: 107-14, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27166580
17.
Multi-parametric assessment of cardiomyocyte excitation-contraction coupling using impedance and field potential recording: A tool for cardiac safety assessment.
J Pharmacol Toxicol Methods
; 81: 201-16, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27282640
18.
Sensitivity of pharmacokinetic-pharmacodynamic analysis for detecting small magnitudes of QTc prolongation in preclinical safety testing.
J Pharmacol Toxicol Methods
; 72: 1-10, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25556117
19.
QT interval correction assessment in the anesthetized guinea pig.
J Pharmacol Toxicol Methods
; 75: 52-61, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26001325
20.
Renal studies in safety pharmacology and toxicology: A survey conducted in the top 15 pharmaceutical companies.
J Pharmacol Toxicol Methods
; 75: 101-10, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25637943