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1.
Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis.
J Pharmacol Exp Ther
; 386(2): 242-258, 2023 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37308266
2.
Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis.
J Pharmacol Exp Ther
; 360(1): 1-13, 2017 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-27754931
3.
Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.
Mol Pharmacol
; 88(6): 982-92, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26371182
4.
Pharmacodynamics, pharmacokinetics and safety of GSK2190915, a novel oral anti-inflammatory 5-lipoxygenase-activating protein inhibitor.
Br J Clin Pharmacol
; 75(3): 779-90, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22803688
5.
JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders.
Sci Rep
; 13(1): 13524, 2023 08 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-37598239
6.
Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation.
J Pharmacol Exp Ther
; 338(1): 290-301, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21487069
7.
Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung.
J Pharmacol Exp Ther
; 332(3): 764-75, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19996299
8.
Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation.
J Pharmacol Exp Ther
; 331(3): 1042-50, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19749079
9.
Author Correction: JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders.
Sci Rep
; 13(1): 20081, 2023 Nov 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-37973811
10.
Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2).
J Med Chem
; 60(10): 4403-4423, 2017 05 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-28471663
11.
Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation.
Eur J Pharmacol
; 640(1-3): 211-8, 2010 Aug 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-20519143
12.
N-Acridin-9-yl-butane-1,4-diamine derivatives: high-affinity ligands of the alpha2delta subunit of voltage gated calcium channels.
Bioorg Med Chem Lett
; 14(8): 1913-6, 2004 Apr 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-15050626
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