Detalles de la búsqueda
1.
The role of intramolecular reactions and chemical degradation in the apparent biotransformation pathways of a series of SYK inhibitors.
Drug Metab Dispos
; 2024 Apr 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-38684371
2.
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorg Med Chem Lett
; 91: 129352, 2023 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37270074
3.
Identification of a novel series of azabenzimidazole-derived inhibitors of spleen tyrosine kinase.
Bioorg Med Chem Lett
; 30(18): 127393, 2020 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32721854
4.
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorg Med Chem Lett
; 30(19): 127433, 2020 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32717371
5.
Development of a quantification method for adenosine in tumors by LC-MS/MS with dansyl chloride derivatization.
Anal Biochem
; 568: 78-88, 2019 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30408457
6.
Exploiting the Inherent Photophysical Properties of the Major Tirapazamine Metabolite in the Development of Profluorescent Substrates for Enzymes That Catalyze the Bioreductive Activation of Hypoxia-Selective Anticancer Prodrugs.
J Org Chem
; 83(6): 3126-3131, 2018 03 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-29461834
7.
Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System.
Drug Metab Dispos
; 45(7): 855-866, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28450578
8.
Application of Suzuki-Miyaura and Buchwald-Hartwig Cross-coupling Reactions to the Preparation of Substituted 1,2,4-Benzotriazine 1-Oxides Related to the Antitumor Agent Tirapazamine.
J Heterocycl Chem
; 54(1): 155-160, 2017 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28439141
9.
Glucocorticoid Clearance and Metabolite Profiling in an In Vitro Human Airway Epithelium Lung Model.
Drug Metab Dispos
; 44(2): 220-6, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26586376
10.
Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor.
Drug Metab Dispos
; 43(7): 1091-9, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25926431
11.
Enzymatic conversion of 6-nitroquinoline to the fluorophore 6-aminoquinoline selectively under hypoxic conditions.
Chem Res Toxicol
; 26(4): 555-63, 2013 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23488987
12.
First Report of Rubber Collection Bowls & Plastic and Bamboo Water Containers as the Major Breeding Source of Ae. albopictus with the Indigenous Transmission of Dengue and Chikungunya in Rural Forested Malaria-Endemic Villages of Dhalai District, Tripura, India: The Importance of Molecular Identification.
Biomedicines
; 11(8)2023 Aug 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-37626683
13.
DNA strand cleavage by the phenazine di-N-oxide natural product myxin under both aerobic and anaerobic conditions.
Chem Res Toxicol
; 25(1): 197-206, 2012 Jan 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-22084973
14.
Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement.
J Med Chem
; 64(20): 15189-15213, 2021 10 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-34647738
15.
Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies.
J Med Chem
; 63(24): 15564-15590, 2020 12 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-33306391
16.
Initiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxide.
J Am Chem Soc
; 131(3): 1015-24, 2009 Jan 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-19117394
17.
Electronic structures and spin topologies of gamma-picoliniumyl radicals. A study of the homolysis of N-methyl-gamma-picolinium and of benzo-, dibenzo-, and naphthoannulated analogs.
J Phys Chem A
; 112(21): 4800-14, 2008 May 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-18494451
18.
Synthesis and biological evaluation of new 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives and their reduced analogues.
J Med Chem
; 50(22): 5485-92, 2007 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17910426
19.
Cytotoxic and pathogenic properties of Klebsiella oxytoca isolated from laboratory animals.
PLoS One
; 9(7): e100542, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25057966
20.
Impact of general versus epidural anesthesia on early post-operative cognitive dysfunction following hip and knee surgery.
J Emerg Trauma Shock
; 4(1): 23-8, 2011 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21633563