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1.
Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats.
Mol Psychiatry
; 28(9): 3829-3841, 2023 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-37783788
2.
Synthesis and biological evaluation of novel 3-(5-substituted-1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with a dual affinity for serotonin 5-HT1A receptor and SERT.
Bioorg Chem
; 141: 106903, 2023 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37827015
3.
Amisulpride as a potential disease-modifying drug in the treatment of tauopathies.
Alzheimers Dement
; 19(12): 5482-5497, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37218673
4.
New Triazine Derivatives as Serotonin 5-HT6 Receptor Ligands.
Molecules
; 28(3)2023 Jan 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36770774
5.
Impact of the Substitution Pattern at the Basic Center and Geometry of the Amine Fragment on 5-HT6 and D3R Affinity in the 1H-Pyrrolo[3,2-c]quinoline Series.
Molecules
; 28(3)2023 Jan 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-36770761
6.
An exit beyond the pharmacophore model for 5-HT6R agents - a new strategy to gain dual 5-HT6/5-HT2A action for triazine derivatives with procognitive potential.
Bioorg Chem
; 121: 105695, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35228010
7.
Design, Synthesis and Biological Evaluation of Novel 1,3,5-Triazines: Effect of Aromatic Ring Decoration on Affinity to 5-HT7 Receptor.
Int J Mol Sci
; 23(21)2022 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36362096
8.
New, Eco-Friendly Method for Synthesis of 3-Chlorophenyl and 1,1'-Biphenyl Piperazinylhexyl Trazodone Analogues with Dual 5-HT1A/5-HT7 Affinity and Its Antidepressant-like Activity.
Molecules
; 27(21)2022 Oct 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-36364104
9.
Candida albicans and Candida glabrata triosephosphate isomerase - a moonlighting protein that can be exposed on the candidal cell surface and bind to human extracellular matrix proteins.
BMC Microbiol
; 21(1): 199, 2021 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34210257
10.
Radioligand and computational insight in structure - Activity relationship of saccharin derivatives being ipsapirone and revospirone analogues.
Bioorg Med Chem Lett
; 42: 128028, 2021 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33839253
11.
The relationship between stereochemical and both, pharmacological and ADME-Tox, properties of the potent hydantoin 5-HT7R antagonist MF-8.
Bioorg Chem
; 106: 104466, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33246603
12.
Neuropathic pain-alleviating activity of novel 5-HT6 receptor inverse agonists derived from 2-aryl-1H-pyrrole-3-carboxamide.
Bioorg Chem
; 115: 105218, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34365058
13.
Antidepressants Differentially Regulate Intracellular Signaling from α1-Adrenergic Receptor Subtypes In Vitro.
Int J Mol Sci
; 22(9)2021 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34062902
14.
The Phenoxyalkyltriazine Antagonists for 5-HT6 Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases.
Int J Mol Sci
; 22(19)2021 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34639113
15.
The Structural Determinants for α1-Adrenergic/Serotonin Receptors Activity among Phenylpiperazine-Hydantoin Derivatives.
Molecules
; 26(22)2021 Nov 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-34834117
16.
Design, Sustainable Synthesis and Biological Evaluation of a Novel Dual α2A/5-HT7 Receptor Antagonist with Antidepressant-Like Properties.
Molecules
; 26(13)2021 Jun 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-34201675
17.
N-Skatyltryptamines-Dual 5-HT6R/D2R Ligands with Antipsychotic and Procognitive Potential.
Molecules
; 26(15)2021 Jul 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-34361754
18.
Synthesis, crystal structure and biological activity of novel analogues of tricyclic drugs.
Bioorg Med Chem Lett
; 30(21): 127493, 2020 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32798652
19.
Chemical puzzles in the search for new, flexible derivatives of lurasidone as antipsychotic drugs.
Bioorg Med Chem
; 28(10): 115459, 2020 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32247749
20.
Aminotriazines with indole motif as novel, 5-HT7 receptor ligands with atypical binding mode.
Bioorg Chem
; 104: 104254, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32919133