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1.
Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes.
J Med Chem
; 66(4): 2622-2645, 2023 02 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36749938
2.
SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response.
Nat Genet
; 55(8): 1311-1323, 2023 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37524790
3.
High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers.
Mol Cancer Ther
; 18(10): 1696-1707, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31575759
4.
Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease.
J Med Chem
; 62(5): 2447-2465, 2019 03 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30779566
5.
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur J Med Chem
; 177: 316-337, 2019 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31158747
6.
Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N8-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722).
J Med Chem
; 61(18): 8226-8240, 2018 09 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-30199249
7.
The effects of adaptive working memory training and mindfulness meditation training on processing efficiency and worry in high worriers.
Behav Res Ther
; 89: 1-13, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27838273
8.
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach.
J Med Chem
; 59(8): 3671-88, 2016 04 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-27055065
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