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1.
A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors.
Bioorg Med Chem Lett
; 47: 128113, 2021 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33991628
2.
The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure.
Bioorg Med Chem
; 28(23): 115791, 2020 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33059303
3.
The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors.
Bioorg Med Chem
; 27(8): 1456-1478, 2019 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30858025
4.
Current Trends in Macrocyclic Drug Discovery and beyond-Ro5.
Prog Med Chem
; 57(1): 113-233, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29680148
5.
Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode.
ACS Med Chem Lett
; 13(11): 1776-1782, 2022 Nov 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36385934
6.
Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand Complexes.
ACS Chem Neurosci
; 13(6): 751-765, 2022 03 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-35245037
7.
Macrolide Inspired Macrocycles as Modulators of the IL-17A/IL-17RA Interaction.
J Med Chem
; 64(12): 8354-8383, 2021 06 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34100601
8.
Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.
J Med Chem
; 62(9): 4683-4702, 2019 05 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30973731
9.
A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660).
J Med Chem
; 61(16): 7314-7329, 2018 08 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-30091600
10.
Identification of inhibitors of protein kinase B using fragment-based lead discovery.
J Med Chem
; 50(10): 2293-6, 2007 May 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-17451234
11.
Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor.
Mol Cancer Ther
; 16(6): 1010-1020, 2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28341788
12.
Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
J Med Chem
; 59(8): 3991-4006, 2016 04 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-27031670
13.
Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors.
ACS Med Chem Lett
; 6(7): 798-803, 2015 Jul 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-26191369
14.
Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.
J Med Chem
; 51(16): 4986-99, 2008 Aug 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-18656911
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