Detalles de la búsqueda
1.
Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV-1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme.
Biochemistry
; 55(16): 2390-400, 2016 04 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-27039930
2.
Mutations Proximal to Sites of Autoproteolysis and the α-Helix That Co-evolve under Drug Pressure Modulate the Autoprocessing and Vitality of HIV-1 Protease.
Biochemistry
; 54(35): 5414-24, 2015 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26266692
3.
Inhibition of autoprocessing of natural variants and multidrug resistant mutant precursors of HIV-1 protease by clinical inhibitors.
Proc Natl Acad Sci U S A
; 108(22): 9072-7, 2011 May 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-21576495
4.
Enhanced stability of monomer fold correlates with extreme drug resistance of HIV-1 protease.
Biochemistry
; 52(43): 7678-88, 2013 Oct 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-24079831
5.
Terminal interface conformations modulate dimer stability prior to amino terminal autoprocessing of HIV-1 protease.
Biochemistry
; 51(5): 1041-50, 2012 Feb 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-22242794
6.
HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements.
Biochemistry
; 51(13): 2819-28, 2012 Apr 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-22404139
7.
Nuclear magnetic resonance solution structure of an N(2)-guanine DNA adduct derived from the potent tumorigen dibenzo[a,l]pyrene: intercalation from the minor groove with ruptured Watson-Crick base pairing.
Biochemistry
; 51(48): 9751-62, 2012 Dec 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-23121427
8.
The L76V drug resistance mutation decreases the dimer stability and rate of autoprocessing of HIV-1 protease by reducing internal hydrophobic contacts.
Biochemistry
; 50(21): 4786-95, 2011 May 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-21446746
9.
Modulation of human immunodeficiency virus type 1 protease autoprocessing by charge properties of surface residue 69.
J Virol
; 83(15): 7789-93, 2009 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-19457992
10.
Interactions of different inhibitors with active-site aspartyl residues of HIV-1 protease and possible relevance to pepsin.
Proteins
; 75(3): 556-68, 2009 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18951411
11.
3'-Intercalation of a N2-dG 1R-trans-anti-benzo[c]phenanthrene DNA adduct in an iterated (CG)3 repeat.
Chem Res Toxicol
; 21(7): 1348-58, 2008 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-18549249
12.
Nucleotide incorporation by human DNA polymerase gamma opposite benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyguanosine and deoxyadenosine.
Nucleic Acids Res
; 32(1): 397-405, 2004.
Artículo
en Inglés
| MEDLINE | ID: mdl-14729924
13.
Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase iota.
Nucleic Acids Res
; 30(23): 5284-92, 2002 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12466554
14.
Benzo[a]pyrene diol epoxide-deoxyguanosine adducts are accurately bypassed by yeast DNA polymerase zeta in vitro.
Mutat Res
; 508(1-2): 137-45, 2002 Oct 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-12379469
15.
Binding of HIV-1 gp41-directed neutralizing and non-neutralizing fragment antibody binding domain (Fab) and single chain variable fragment (ScFv) antibodies to the ectodomain of gp41 in the pre-hairpin and six-helix bundle conformations.
PLoS One
; 9(8): e104683, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25105806
16.
Extreme multidrug resistant HIV-1 protease with 20 mutations is resistant to novel protease inhibitors with P1'-pyrrolidinone or P2-tris-tetrahydrofuran.
J Med Chem
; 56(10): 4017-27, 2013 May 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-23590295
17.
Mechanism of dissociative inhibition of HIV protease and its autoprocessing from a precursor.
J Mol Biol
; 422(2): 230-44, 2012 Sep 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-22659320
18.
Autocatalytic maturation, physical/chemical properties, and crystal structure of group N HIV-1 protease: relevance to drug resistance.
Protein Sci
; 19(11): 2055-72, 2010 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-20737578
19.
Marked Differences in Base Selectivity between DNA and the Free Nucleotides upon Adduct Formation from Bay- and Fjord-Region Diol Epoxides Volume 13, Number 9, September 2000, pp 883-890.
Chem Res Toxicol
; 14(1): 148, 2001 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-11749530
20.
Revealing the dimer dissociation and existence of a folded monomer of the mature HIV-2 protease.
Protein Sci
; 18(12): 2442-53, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19798742