Detalles de la búsqueda
1.
Detecting Protein-Ligand Interactions with Nitroxide Based Paramagnetic Cosolutes.
Chemistry
; 30(18): e202303570, 2024 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38018494
2.
Groebke Blackburn Bienaymé-mediated multi-component synthesis of selective HDAC6 inhibitors with anti-inflammatory properties.
Bioorg Chem
; 143: 107072, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38185013
3.
Solid-Phase Parallel Synthesis of Dual Histone Deacetylase-Cyclooxygenase Inhibitors.
Molecules
; 28(3)2023 Jan 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-36770730
4.
Hydroxamic Acids Immobilized on Resins (HAIRs): Synthesis of Dual-Targeting HDAC Inhibitors and HDAC Degraders (PROTACs).
Angew Chem Int Ed Engl
; 59(50): 22494-22499, 2020 12 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32780485
5.
Fluorescent analogs of peptoid-based HDAC inhibitors: Synthesis, biological activity and cellular uptake kinetics.
Bioorg Med Chem
; 27(19): 115039, 2019 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31420257
6.
Preferential HDAC6 inhibitors derived from HPOB exhibit synergistic antileukemia activity in combination with decitabine.
Eur J Med Chem
; 272: 116447, 2024 Jun 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-38714044
7.
Solid-Phase Synthesis of Cereblon-Recruiting Selective Histone Deacetylase 6 Degraders (HDAC6 PROTACs) with Antileukemic Activity.
J Med Chem
; 65(24): 16860-16878, 2022 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36473103
8.
Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia.
J Med Chem
; 65(22): 15457-15472, 2022 11 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-36351184
9.
Balancing Histone Deacetylase (HDAC) Inhibition and Drug-likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors.
ChemMedChem
; 17(9): e202100755, 2022 05 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35073610
10.
Synthesis, Antiplasmodial, and Antileukemia Activity of Dihydroartemisinin-HDAC Inhibitor Hybrids as Multitarget Drugs.
Pharmaceuticals (Basel)
; 15(3)2022 Mar 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35337131
11.
Antiproliferation and Antiencystation Effect of Class II Histone Deacetylase Inhibitors on Acanthamoeba castellanii.
ACS Infect Dis
; 8(2): 271-279, 2022 02 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34994538
12.
Borinostats: solid-phase synthesis of carborane-capped histone deacetylase inhibitors with a tailor-made selectivity profile.
Chem Sci
; 12(35): 11873-11881, 2021 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34659728
13.
Oxa Analogues of Nexturastatâ A Demonstrate Improved HDAC6 Selectivity and Superior Antileukaemia Activity.
ChemMedChem
; 16(11): 1798-1803, 2021 06 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33629513
14.
4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads.
J Med Chem
; 64(19): 14620-14646, 2021 10 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-34582215
15.
Investigation of the in vitro and in vivo efficacy of peptoid-based HDAC inhibitors with dual-stage antiplasmodial activity.
Eur J Med Chem
; 211: 113065, 2021 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33360801
16.
Multicomponent Synthesis, Binding Mode, and Structure-Activity Relationship of Selective Histone Deacetylase 6 (HDAC6) Inhibitors with Bifurcated Capping Groups.
J Med Chem
; 63(18): 10339-10351, 2020 09 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-32803970
17.
Fluorinated Analogues of the Histone Deacetylase Inhibitor Vorinostat (Zolinza): Validation of a Chiral Hybrid Bioisostere, BITE.
ACS Med Chem Lett
; 10(9): 1336-1340, 2019 Sep 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31531206
18.
Design, synthesis and biological evaluation of ß-peptoid-capped HDAC inhibitors with anti-neuroblastoma and anti-glioblastoma activity.
Medchemcomm
; 10(7): 1109-1115, 2019 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31391882
19.
Structure-Activity and Structure-Toxicity Relationships of Peptoid-Based Histone Deacetylase Inhibitors with Dual-Stage Antiplasmodial Activity.
ChemMedChem
; 14(9): 912-926, 2019 05 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30664827
20.
Multicomponent Synthesis and Binding Mode of Imidazo[1,2- a]pyridine-Capped Selective HDAC6 Inhibitors.
Org Lett
; 20(11): 3255-3258, 2018 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29790770