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1.
Calcitonin gene-related peptide (CGRP) receptor antagonists: Heterocyclic modification of a novel azepinone lead.
Bioorg Med Chem Lett
; 43: 128077, 2021 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33932522
2.
Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists.
Bioorg Med Chem Lett
; 31: 127624, 2021 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33096162
3.
Utilization of In Vitro, In Vivo and In Silico Tools to Evaluate the pH-Dependent Absorption of a BCS Class II Compound and Identify a pH-Effect Mitigating Strategy.
Pharm Res
; 36(12): 164, 2019 Oct 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31637544
4.
Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers.
Proc Natl Acad Sci U S A
; 108(37): 15366-71, 2011 Sep 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-21896751
5.
Preparation of imidazoles as potent calcitonin gene-related peptide (CGRP) antagonists.
Bioorg Med Chem Lett
; 23(20): 5684-8, 2013 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23993336
6.
The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2.
Bioorg Med Chem Lett
; 23(6): 1870-3, 2013 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23402880
7.
Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery.
Bioorg Med Chem Lett
; 23(11): 3157-61, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23632269
8.
The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1.
Bioorg Med Chem Lett
; 22(14): 4723-7, 2012 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22727645
9.
Carbamates as potent calcitonin gene-related peptide antagonists with improved solution stability.
Bioorg Med Chem Lett
; 19(13): 3555-8, 2009 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19467597
10.
On the thermodynamics of cocrystal formation.
Int J Pharm
; 365(1-2): 77-80, 2009 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-18804155
11.
Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.
J Med Chem
; 59(17): 8042-60, 2016 09 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27564532
12.
The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection.
J Med Chem
; 57(5): 1730-52, 2014 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24564672
13.
Surfactant choice and the physical stability of nanosuspensions as a function of pH.
Int J Pharm
; 439(1-2): 1-7, 2012 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22982488
14.
Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): an oral calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraine.
J Med Chem
; 55(23): 10644-51, 2012 Dec 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-23153230
15.
Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine.
ACS Med Chem Lett
; 3(4): 337-41, 2012 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900474
16.
A strategy to minimize reactive metabolite formation: discovery of (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a potent, orally bioavailable corticotropin-releasing factor-1 receptor antagonist.
J Med Chem
; 52(23): 7653-68, 2009 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-19954247
17.
Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure.
J Med Chem
; 51(16): 4858-61, 2008 Aug 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-18665579
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