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1.
Stabilization of Monomeric Tau Protein by All D-Enantiomeric Peptide Ligands as Therapeutic Strategy for Alzheimer's Disease and Other Tauopathies.
Int J Mol Sci
; 24(3)2023 Jan 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-36768484
2.
In Vitro and In Vivo Efficacies of the Linear and the Cyclic Version of an All-d-Enantiomeric Peptide Developed for the Treatment of Alzheimer's Disease.
Int J Mol Sci
; 22(12)2021 Jun 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34207233
3.
PEAß Triggers Cognitive Decline and Amyloid Burden in a Novel Mouse Model of Alzheimer's Disease.
Int J Mol Sci
; 22(13)2021 Jun 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-34209113
4.
Deceleration of the neurodegenerative phenotype in pyroglutamate-Aß accumulating transgenic mice by oral treatment with the Aß oligomer eliminating compound RD2.
Neurobiol Dis
; 124: 36-45, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30391539
5.
Large-Scale Oral Treatment Study with the Four Most Promising D3-Derivatives for the Treatment of Alzheimer's Disease.
Molecules
; 22(10)2017 Oct 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28994710
6.
Cryo-EM of Aß fibrils from mouse models find tg-APPArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat Neurosci
; 26(12): 2073-2080, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37973869
7.
Oral treatment with the all-d-peptide RD2 enhances cognition in aged beagle dogs - A model of sporadic Alzheimer's disease.
Heliyon
; 9(8): e18443, 2023 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-37609390
8.
Aß oligomer concentration in mouse and human brain and its drug-induced reduction ex vivo.
Cell Rep Med
; 3(5): 100630, 2022 05 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-35584626
9.
Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin.
Nat Commun
; 13(1): 2363, 2022 05 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35501361
10.
Sex-Related Motor Deficits in the Tau-P301L Mouse Model.
Biomedicines
; 9(9)2021 Sep 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-34572348
11.
Oral absorption enhancement of the amyloid-ß oligomer eliminating compound RD2 by conjugation with folic acid.
Eur J Pharm Sci
; 156: 105581, 2021 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33035662
12.
Comparison of the Amyloid Load in the Brains of Two Transgenic Alzheimer's Disease Mouse Models Quantified by Florbetaben Positron Emission Tomography.
Front Neurosci
; 15: 699926, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34671235
13.
Aß Oligomer Elimination Restores Cognition in Transgenic Alzheimer's Mice with Full-blown Pathology.
Mol Neurobiol
; 56(3): 2211-2223, 2019 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-30003517
14.
Development and validation of an UHPLC-ESI-QTOF-MS method for quantification of the highly hydrophilic amyloid-ß oligomer eliminating all-D-enantiomeric peptide RD2 in mouse plasma.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1073: 123-129, 2018 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29248770
15.
In Vitro Potency and Preclinical Pharmacokinetic Comparison of All-D-Enantiomeric Peptides Developed for the Treatment of Alzheimer's Disease.
J Alzheimers Dis
; 64(3): 859-873, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29966196
16.
Comparison of blood-brain barrier penetration efficiencies between linear and cyclic all-d-enantiomeric peptides developed for the treatment of Alzheimer's disease.
Eur J Pharm Sci
; 114: 93-102, 2018 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29225107
17.
Comprehensive Characterization of the Pyroglutamate Amyloid-ß Induced Motor Neurodegenerative Phenotype of TBA2.1 Mice.
J Alzheimers Dis
; 63(1): 115-130, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29578479
18.
Aß oligomer eliminating compounds interfere successfully with pEAß(3-42) induced motor neurodegenerative phenotype in transgenic mice.
Neuropeptides
; 67: 27-35, 2018 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-29273382
19.
The Aß oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology.
Sci Rep
; 7(1): 16275, 2017 11 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-29176708
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