Detalles de la búsqueda
1.
Metabolism, pharmacokinetics, and anticonvulsant activity of a deuterated analog of the α2/3-selective GABAkine KRM-II-81.
Biopharm Drug Dispos
; 43(2): 66-75, 2022 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-35194800
2.
Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine 1-Phosphate Receptor Subtypes 1 and 5.
J Pharmacol Exp Ther
; 379(3): 386-399, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34535564
3.
Synthesis of (-)-11-O-Debenzoyltashironin: Neurotrophic Sesquiterpenes Cause Hyperexcitation.
J Am Chem Soc
; 139(28): 9637-9644, 2017 07 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-28644021
4.
Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache.
Bioorg Med Chem Lett
; 27(2): 323-328, 2017 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27908761
5.
Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression.
Bioorg Med Chem Lett
; 26(23): 5663-5668, 2016 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27836401
6.
N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes.
J Pharmacol Exp Ther
; 336(1): 165-77, 2011 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-20947638
7.
Negative allosteric modulation of alpha 5-containing GABAA receptors engenders antidepressant-like effects and selectively prevents age-associated hyperactivity in tau-depositing mice.
Psychopharmacology (Berl)
; 235(4): 1151-1161, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29374303
8.
Pharmacological characterization of the neurotrophic sesquiterpene jiadifenolide reveals a non-convulsant signature and potential for progression in neurodegenerative disease studies.
Biochem Pharmacol
; 155: 61-70, 2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29940173
9.
Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy.
J Med Chem
; 59(23): 10800-10806, 2016 12 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27933953
10.
Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
J Med Chem
; 59(24): 10974-10993, 2016 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28002967
11.
The pharmacology of LXR.
Mini Rev Med Chem
; 5(8): 729-40, 2005 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-16101409
12.
Group II metabotropic glutamate receptor type 2 allosteric potentiators prevent sodium lactate-induced panic-like response in panic-vulnerable rats.
J Psychopharmacol
; 27(2): 152-61, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22914798
13.
Prospects for metabotropic glutamate 1 receptor antagonists in the treatment of neuropathic pain.
J Med Chem
; 50(11): 2563-8, 2007 May 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-17489573
14.
Activation of metabotropic glutamate (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge.
Neuropharmacology
; 58(3): 632-9, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19951716
15.
Discovery of aminoglycoside mimetics by NMR-based screening of Escherichia coli A-site RNA.
J Am Chem Soc
; 125(15): 4444-50, 2003 Apr 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-12683814
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