Detalles de la búsqueda
1.
Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes.
J Pharmacol Exp Ther
; 370(1): 72-83, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30975793
2.
Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites.
Drug Metab Dispos
; 47(10): 1080-1092, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31399506
3.
Mechanistic Evaluation of the Complex Drug-Drug Interactions of Maraviroc: Contribution of Cytochrome P450 3A, P-Glycoprotein and Organic Anion Transporting Polypeptide 1B1.
Drug Metab Dispos
; 47(5): 493-503, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30862625
4.
Transporter-Mediated Disposition, Clinical Pharmacokinetics and Cholestatic Potential of Glyburide and Its Primary Active Metabolites.
Drug Metab Dispos
; 45(7): 737-747, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28438781
5.
Elucidation of the Mechanisms through Which the Reactive Metabolite Diclofenac Acyl Glucuronide Can Mediate Toxicity.
J Pharmacol Exp Ther
; 357(1): 167-76, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26869668
6.
The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide-Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy.
Drug Metab Dispos
; 44(5): 692-9, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26888941
7.
Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia/Cholestasis.
Chem Res Toxicol
; 29(10): 1778-1788, 2016 Oct 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-27676153
8.
Multidrug Resistance-Associated Protein 3 Plays an Important Role in Protection against Acute Toxicity of Diclofenac.
Drug Metab Dispos
; 43(7): 944-50, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25897176
9.
Hepatic Disposition of Gemfibrozil and Its Major Metabolite Gemfibrozil 1-O-ß-Glucuronide.
Mol Pharm
; 12(11): 3943-52, 2015 Nov 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-26378985
10.
Toward a unified model of passive drug permeation II: the physiochemical determinants of unbound tissue distribution with applications to the design of hepatoselective glucokinase activators.
Drug Metab Dispos
; 42(10): 1599-610, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25024402
11.
Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574.
J Pharmacol Exp Ther
; 347(1): 212-24, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-23899905
12.
Elucidation of the biochemical basis for a clinical drug-drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha.
Xenobiotica
; 43(11): 963-72, 2013 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-23631744
13.
Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator.
Toxicol Sci
; 194(2): 235-245, 2023 07 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-37261863
14.
Using Simcyp to project human oral pharmacokinetic variability in early drug research to mitigate mechanism-based adverse events.
Biopharm Drug Dispos
; 33(2): 72-84, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22213407
15.
Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution.
Bioorg Med Chem Lett
; 21(9): 2725-31, 2011 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21183342
16.
Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes.
J Pharm Sci
; 110(1): 376-387, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33122051
17.
The modulation of transcriptional expression and inhibition of multidrug resistance associated protein 4 (MRP4) by analgesics and their primary metabolites.
Curr Res Toxicol
; 1: 34-41, 2020 Jun 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34345835
18.
Cell-to-Medium Concentration Ratio Overshoot in the Uptake of Statins by Human Hepatocytes in Suspension, but Not in Monolayer: Kinetic Analysis Suggesting a Partial Loss of Functional OATP1Bs.
AAPS J
; 22(6): 133, 2020 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33063163
19.
Xenobiotic Transporters in the Kidney: Function and Role in Toxicity.
Semin Nephrol
; 39(2): 159-175, 2019 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-30827339
20.
Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.
AAPS J
; 19(3): 787-796, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28188574