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1.
Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor.
Bioorg Med Chem Lett
; 27(11): 2634-2640, 2017 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28416131
2.
The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-α-chloro-2'-ß-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors.
Bioorg Med Chem Lett
; 27(18): 4323-4330, 2017 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28835346
3.
Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase.
Bioorg Med Chem Lett
; 26(18): 4536-4541, 2016 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27520942
4.
Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease.
Bioorg Med Chem Lett
; 25(18): 3984-91, 2015 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26231161
5.
Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320.
Bioorg Med Chem Lett
; 25(22): 5427-36, 2015 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26410074
6.
Synthesis of 2'-O,4'-C-alkylene-bridged ribonucleosides and their evaluation as inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 24(12): 2699-702, 2014 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24815510
7.
Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease.
Bioorg Med Chem Lett
; 24(18): 4444-4449, 2014 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25155387
8.
2'-C-Methyl branched pyrimidine ribonucleoside analogues: potent inhibitors of RNA virus replication.
Antivir Chem Chemother
; 18(4): 225-42, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17907380
9.
Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor.
J Med Chem
; 59(5): 1891-8, 2016 Mar 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26804933
10.
Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor.
Future Med Chem
; 7(13): 1675-700, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26424162
11.
Synthesis and biological evaluation of aryl-phospho-indole as novel HIV-1 non-nucleoside reverse transcriptase inhibitors.
J Med Chem
; 54(1): 392-5, 2011 Jan 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-21142105
12.
Telbivudine, a nucleoside analog inhibitor of HBV polymerase, has a different in vitro cross-resistance profile than the nucleotide analog inhibitors adefovir and tenofovir.
Antiviral Res
; 81(2): 147-55, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19028525
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