Detalles de la búsqueda
1.
Effects of Repeated Treatment with the Monoacylglycerol Lipase Inhibitor MJN110 on Pain-Related Depression of Nesting and Cannabinoid 1 Receptor Function in Male and Female Mice.
J Pharmacol Exp Ther
; 2024 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38262742
2.
Blocking potential metabolic sites on NAT to improve its safety profile while retaining the pharmacological profile.
Bioorg Chem
; 148: 107489, 2024 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-38797065
3.
Novel bivalent ligands carrying potential antinociceptive effects by targeting putative mu opioid receptor and chemokine receptor CXCR4 heterodimers.
Bioorg Chem
; 120: 105641, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35093692
4.
A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists.
Molecules
; 27(19)2022 Sep 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-36234992
5.
Exploring naltrexamine derivatives featuring azaindole moiety via nitrogen-walk approach to investigate their in vitro pharmacological profiles at the mu opioid receptor.
Bioorg Med Chem Lett
; 41: 127953, 2021 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33766769
6.
Verifying the role of 3-hydroxy of 17-cyclopropylmethyl-4,5α-epoxy-3,14ß-dihydroxy-6ß-[(4'-pyridyl) carboxamido]morphinan derivatives via their binding affinity and selectivity profiles on opioid receptors.
Bioorg Chem
; 109: 104702, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33631465
7.
Differential Tolerance to FTY720-Induced Antinociception in Acute Thermal and Nerve Injury Mouse Pain Models: Role of Sphingosine-1-Phosphate Receptor Adaptation.
J Pharmacol Exp Ther
; 366(3): 509-518, 2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29945931
8.
Cannabinoid Receptor Interacting Protein 1a Competition with ß-Arrestin for CB1 Receptor Binding Sites.
Mol Pharmacol
; 91(2): 75-86, 2017 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-27895162
9.
Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner.
J Neurochem
; 139(3): 396-407, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27513693
10.
Central HIV-1 Tat exposure elevates anxiety and fear conditioned responses of male mice concurrent with altered mu-opioid receptor-mediated G-protein activation and ß-arrestin 2 activity in the forebrain.
Neurobiol Dis
; 92(Pt B): 124-36, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26845176
11.
Discriminative Stimulus Properties of the Endocannabinoid Catabolic Enzyme Inhibitor SA-57 in Mice.
J Pharmacol Exp Ther
; 358(2): 306-14, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27307500
12.
Efficacy of Hybrid Tetrahydrobenzo[d]thiazole Based Aryl Piperazines D-264 and D-301 at D2 and D3 Receptors.
Neurochem Res
; 41(1-2): 328-339, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26718829
13.
Exploration of bivalent ligands targeting putative mu opioid receptor and chemokine receptor CCR5 dimerization.
Bioorg Med Chem
; 24(22): 5969-5987, 2016 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27720326
14.
Mutation of putative GRK phosphorylation sites in the cannabinoid receptor 1 (CB1R) confers resistance to cannabinoid tolerance and hypersensitivity to cannabinoids in mice.
J Neurosci
; 34(15): 5152-63, 2014 Apr 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-24719095
15.
Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation.
Mol Pharmacol
; 87(4): 747-65, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25657338
16.
Role of Dopamine Type 1 Receptors and Dopamine- and cAMP-Regulated Phosphoprotein Mr 32 kDa in Δ9-Tetrahydrocannabinol-Mediated Induction of ΔFosB in the Mouse Forebrain.
J Pharmacol Exp Ther
; 354(3): 316-27, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-26099530
17.
Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice.
J Pharmacol Exp Ther
; 354(2): 111-20, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-25998048
18.
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14ß-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.
Bioorg Med Chem
; 23(8): 1701-15, 2015 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25783191
19.
Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells.
J Pharmacol Exp Ther
; 348(2): 293-302, 2014 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-24259678
20.
Prolonged monoacylglycerol lipase blockade causes equivalent cannabinoid receptor type 1 receptor-mediated adaptations in fatty acid amide hydrolase wild-type and knockout mice.
J Pharmacol Exp Ther
; 350(2): 196-204, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24849924