Detalles de la búsqueda
1.
Discovery of two novel (4-hydroxyphenyl) substituted polycyclic carbocycles as potent and selective estrogen receptor beta agonists.
Bioorg Med Chem Lett
; 73: 128906, 2022 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35870729
2.
Long-term oral administration of a novel estrogen receptor beta agonist enhances memory and alleviates drug-induced vasodilation in young ovariectomized mice.
Horm Behav
; 130: 104948, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33571507
3.
Synthesis and evaluation of 17α-triazolyl and 9α-cyano derivatives of estradiol.
Bioorg Med Chem
; 28(19): 115670, 2020 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32912438
4.
Role of Conserved Histidine and Serine in the HCXXXXXRS Motif of Human Dual-Specificity Phosphatase 5.
J Chem Inf Model
; 59(4): 1563-1574, 2019 04 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-30835471
5.
Discovery and Characterization of Halogenated Xanthene Inhibitors of DUSP5 as Potential Photodynamic Therapeutics.
J Photochem Photobiol A Chem
; 375: 114-131, 2019 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31839699
6.
Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor.
BMC Biochem
; 18(1): 10, 2017 05 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-28569147
7.
Critical Role of the Secondary Binding Pocket in Modulating the Enzymatic Activity of DUSP5 toward Phosphorylated ERKs.
Biochemistry
; 55(44): 6187-6195, 2016 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27739308
8.
Generation of Molecular Complexity from Cyclooctatetraene: Preparation of Aminobicyclo[5.1.0]octitols.
Chemistry
; 21(30): 10886-95, 2015 Jul 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-26096989
9.
Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets.
BMC Biochem
; 16: 19, 2015 Aug 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-26286528
10.
Protein expression, characterization and activity comparisons of wild type and mutant DUSP5 proteins.
BMC Biochem
; 15: 27, 2014 Dec 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-25519881
11.
Probing the human estrogen receptor-α binding requirements for phenolic mono- and di-hydroxyl compounds: a combined synthesis, binding and docking study.
Bioorg Med Chem
; 22(1): 303-10, 2014 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24315190
12.
Correction to "Critical Role of the Secondary Binding Pocket in Modulating the Enzymatic Activity of DUSP5 toward Phosphorylated ERKs".
Biochemistry
; 57(26): 3987, 2018 07 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29897735
13.
Solution structures of Mycobacterium tuberculosis thioredoxin C and models of intact thioredoxin system suggest new approaches to inhibitor and drug design.
Proteins
; 81(4): 675-89, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23229911
14.
Molecular docking and NMR binding studies to identify novel inhibitors of human phosphomevalonate kinase.
Biochem Biophys Res Commun
; 430(1): 313-9, 2013 Jan 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-23146631
15.
Real-time thiol detection in iPSC-derived neuron cultures using SemKur-IM, a novel fluorescent dithio probe.
SLAS Discov
; 29(3): 100127, 2023 Nov 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38000947
16.
Solution phase refinement of active site structure using 2D NMR and judiciously 13C-labeled cytochrome P450.
J Inorg Biochem
; 241: 112126, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36682280
17.
NMR dynamics investigation of ligand-induced changes of main and side-chain arginine N-H's in human phosphomevalonate kinase.
J Am Chem Soc
; 132(7): 2102-3, 2010 Feb 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-20112895
18.
Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism.
Proteins
; 75(1): 127-38, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-18798562
19.
13C-Methyl isocyanide as an NMR probe for cytochrome P450 active sites.
J Biomol NMR
; 43(3): 171-8, 2009 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19199046
20.
Conserved amino acids in each subunit of the heteroligomeric tRNA m1A58 Mtase from Saccharomyces cerevisiae contribute to tRNA binding.
Nucleic Acids Res
; 35(20): 6808-19, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17932071