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1.
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
Biochem Biophys Res Commun
; 555: 134-139, 2021 05 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-33813272
2.
Preclinical Characterization and Human Microdose Pharmacokinetics of ITMN-8187, a Nonmacrocyclic Inhibitor of the Hepatitis C Virus NS3 Protease.
Antimicrob Agents Chemother
; 61(1)2017 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27795376
3.
Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate.
PLoS Pathog
; 11(6): e1004995, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-26098424
4.
Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C.
J Med Chem
; 63(18): 10380-10395, 2020 09 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-32816483
5.
The Effect of Equal-Channel Angular Pressing on the Microstructure, the Mechanical and Corrosion Properties and the Anti-Tumor Activity of Magnesium Alloyed with Silver.
Materials (Basel)
; 12(23)2019 Nov 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31766395
6.
Synthesis and Anti-HCV Activities of 4'-Fluoro-2'-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4'-Fluoro-2'- C-methyluridine 5'-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection.
J Med Chem
; 62(9): 4555-4570, 2019 05 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30951311
7.
Preclinical characteristics of the hepatitis C virus NS3/4A protease inhibitor ITMN-191 (R7227).
Antimicrob Agents Chemother
; 52(12): 4432-41, 2008 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-18824605
8.
Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection.
J Med Chem
; 58(4): 1862-78, 2015 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25667954
9.
Synthesis of N-acetyl-D-galactosamine and folic acid conjugated ribozymes.
Bioconjug Chem
; 13(5): 1071-8, 2002.
Artículo
en Inglés
| MEDLINE | ID: mdl-12236789
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