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1.
HCV genotype 1-6 NS3 residue 80 substitutions impact protease inhibitor activity and promote viral escape.
J Hepatol
; 70(3): 388-397, 2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30395912
2.
Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.
Antimicrob Agents Chemother
; 60(6): 3563-78, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27021330
3.
Substitutions at NS3 Residue 155, 156, or 168 of Hepatitis C Virus Genotypes 2 to 6 Induce Complex Patterns of Protease Inhibitor Resistance.
Antimicrob Agents Chemother
; 59(12): 7426-36, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26392503
4.
Hypervariable region 1 deletion and required adaptive envelope mutations confer decreased dependency on scavenger receptor class B type I and low-density lipoprotein receptor for hepatitis C virus.
J Virol
; 88(3): 1725-39, 2014 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-24257605
5.
Identification of alpha interferon-induced envelope mutations of hepatitis C virus in vitro associated with increased viral fitness and interferon resistance.
J Virol
; 87(23): 12776-93, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24049176
6.
Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses.
Antimicrob Agents Chemother
; 57(3): 1291-303, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23274664
7.
Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor.
Antimicrob Agents Chemother
; 57(12): 6034-49, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24060868
8.
Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization.
J Virol
; 85(5): 2224-34, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21123377
9.
Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A.
J Virol
; 85(17): 8913-28, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21697486
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