Detalles de la búsqueda
1.
Tailored horseshoe-shaped nicotinonitrile scaffold as dual promising c-Met and Pim-1 inhibitors: Design, synthesis, SAR and in silico study.
Bioorg Chem
; 143: 106988, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-37995644
2.
New coumarin linked thiazole derivatives as antimycobacterial agents: Design, synthesis, enoyl acyl carrier protein reductase (InhA) inhibition and molecular modeling.
Bioorg Chem
; 150: 107511, 2024 May 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-38870705
3.
Development of new thieno[2,3-d]pyrimidines as dual EGFR and STAT3 inhibitors endowed with anticancer and pro-apoptotic activities.
Bioorg Chem
; 143: 107101, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38183682
4.
Identification of 3-(5-cyano-6-oxo-pyridin-2-yl)benzenesulfonamides as novel anticancer agents endowed with EGFR inhibitory activity.
Arch Pharm (Weinheim)
; 357(1): e2300449, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-37828544
5.
Novel 4-(2-arylidenehydrazineyl)thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico insights.
Bioorg Chem
; 140: 106799, 2023 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37625210
6.
Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors.
J Enzyme Inhib Med Chem
; 38(1): 2203389, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37122176
7.
Chronotherapeutic neuroprotective effect of verapamil against lipopolysaccharide-induced neuroinflammation in mice through modulation of calcium-dependent genes.
Mol Med
; 28(1): 139, 2022 11 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-36435759
8.
Ketoprofen, piroxicam and indomethacin-suppressed quorum sensing and virulence factors in Acinetobacter baumannii.
J Appl Microbiol
; 133(4): 2182-2197, 2022 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-35503000
9.
Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition.
Bioorg Chem
; 129: 106126, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36108589
10.
New tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies.
Bioorg Chem
; 120: 105644, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35121552
11.
Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity.
J Enzyme Inhib Med Chem
; 37(1): 1043-1052, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-35437108
12.
Could the analgesic drugs, paracetamol and indomethacin, function as quorum sensing inhibitors?
Microb Pathog
; 158: 105097, 2021 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-34284088
13.
Development of Novel Quinoline-Based Sulfonamides as Selective Cancer-Associated Carbonic Anhydrase Isoform IX Inhibitors.
Int J Mol Sci
; 22(20)2021 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34681794
14.
Drugs with new lease of life as quorum sensing inhibitors: for combating MDR Acinetobacter baumannii infections.
Eur J Clin Microbiol Infect Dis
; 39(9): 1687-1702, 2020 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-32328851
15.
New thiazolopyrimidine as anticancer agents: Synthesis, biological evaluation, DNA binding, molecular modeling and ADMET study.
Bioorg Med Chem Lett
; 30(23): 127611, 2020 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33068712
16.
Synthesis of imidazolidine-2,4-dione and 2-thioxoimidazolidin-4-one derivatives as inhibitors of virulence factors production in Pseudomonas aeruginosa.
Arch Pharm (Weinheim)
; 353(5): e1900352, 2020 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-32134150
17.
Synthesis, Evaluation of Pharmacological Activity, and Molecular Docking of 1,4-Dihydropyridines as Calcium Antagonists.
Chem Pharm Bull (Tokyo)
; 64(4): 297-304, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26822207
18.
Study of the binding interaction of salmon sperm DNA with nintedanib, a tyrosine kinase inhibitor using multi-spectroscopic, thermodynamic, and in silico approaches.
J Biomol Struct Dyn
; 42(3): 1170-1180, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-37079322
19.
A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments.
Eur J Med Chem
; 274: 116527, 2024 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-38810335
20.
DFT and molecular simulation validation of the binding activity of PDEδ inhibitors for repression of oncogenic k-Ras.
PLoS One
; 19(3): e0300035, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38457483