Detalles de la búsqueda
1.
Comprehensive characterization and preclinical assessment of an imidazopyridine-based anticancer lead molecule.
Drug Dev Res
; 85(1): e22139, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38084651
2.
Assessment of metabolic stability and pharmacokinetics by LC-MS/MS and establishment of the safe dose of IMID-2, a novel anticancer molecule under drug discovery.
Biomed Chromatogr
; 37(6): e5618, 2023 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-36882885
3.
Boronic acid derivative activates pyruvate kinase M2 indispensable for redox metabolism in oral cancer cells.
Bioorg Med Chem Lett
; 59: 128539, 2022 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35007726
4.
Discovery of boronic acid-based potent activators of tumor pyruvate kinase M2 and development of gastroretentive nanoformulation for oral dosing.
Bioorg Med Chem Lett
; 42: 128062, 2021 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33901643
5.
Pyruvate kinase M2 in chronic inflammations: a potpourri of crucial protein-protein interactions.
Cell Biol Toxicol
; 37(5): 653-678, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33864549
6.
Metabolite profiling of IMID-2, a novel anticancer molecule of piperazine derivative: In silico prediction, in vitro and in vivo metabolite characterization using UPLC-QTOF-MS/MS.
Biomed Chromatogr
; 35(6): e5082, 2021 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-33570183
7.
Potassium tert-butoxide mediated C-C, C-N, C-O and C-S bond forming reactions.
Org Biomol Chem
; 18(41): 8346-8365, 2020 11 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33020791
8.
Styryl-cinnamate hybrid inhibits glioma by alleviating translation, bioenergetics and other key cellular responses leading to apoptosis.
Exp Cell Res
; 375(1): 11-21, 2019 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30513337
9.
Drug development and bioanalytical method validation for a novel anticancer molecule, 4-(dimethylamino)-2-(p-tolylamino) thiazole-5-carbonitrile.
Drug Dev Res
; 79(8): 391-399, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30329161
10.
Thiol-ene "click" reaction triggered by neutral ionic liquid: the "ambiphilic" character of [hmim]Br in the regioselective nucleophilic hydrothiolation.
Angew Chem Int Ed Engl
; 54(3): 828-32, 2015 Jan 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25430704
11.
Imidazopyrimidine: from a relatively exotic scaffold to an evolving structural motif in drug discovery.
RSC Med Chem
; 15(5): 1488-1507, 2024 May 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-38784469
12.
Rare diseases and pyruvate kinase M2: a promising therapeutic connection.
Drug Discov Today
; 29(5): 103949, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38492882
13.
Glucose regulation by newly synthesized boronic acid functionalized molecules as dipeptidyl peptidase IV inhibitor: a potential compound for therapeutic intervention in hyperglycaemia.
J Biomol Struct Dyn
; 42(6): 2859-2871, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-37254302
14.
Mechanistic Investigation of Thiazole-Based Pyruvate Kinase M2 Inhibitor Causing Tumor Regression in Triple-Negative Breast Cancer.
J Med Chem
; 67(5): 3339-3357, 2024 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38408027
15.
Roadmap to Pyruvate Kinase M2 Modulation - A Computational Chronicle.
Curr Drug Targets
; 24(6): 464-483, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36998144
16.
PROTACting the kinome with covalent warheads.
Drug Discov Today
; 28(1): 103417, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36306996
17.
Self-regulated cobalt zinc ferrite system as a potential nanoplatform for the synergistic effect of hyperthermia-chemo agent for cancer therapy.
Colloids Surf B Biointerfaces
; 222: 113077, 2023 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-36577341
18.
Palladium-catalyzed dehydrative heck olefination of secondary aryl alcohols in ionic liquids: towards a waste-free strategy for tandem synthesis of stilbenoids.
Angew Chem Int Ed Engl
; 51(11): 2636-9, 2012 Mar 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-22298495
19.
A molecular perspective for the use of type IV tyrosine kinase inhibitors as anticancer therapeutics.
Drug Discov Today
; 27(3): 808-821, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34920095
20.
Objective assessment of adrenocortical carcinoma driver genes and their correlation with tumor pyruvate kinase M2.
Gene
; 822: 146354, 2022 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35189247