Detalles de la búsqueda
1.
Effects of Monoclonal Antibodies against Nerve Growth Factor on Healthy Bone and Joint Tissues in Mice, Rats, and Monkeys: Histopathologic, Biomarker, and Microcomputed Tomographic Assessments.
Toxicol Pathol
; 46(4): 408-420, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29768985
2.
Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain.
J Biol Chem
; 291(27): 13974-13986, 2016 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27129258
3.
Nerve growth factor inhibition with tanezumab influences weight-bearing and subsequent cartilage damage in the rat medial meniscal tear model.
Ann Rheum Dis
; 76(1): 295-302, 2017 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-27381034
4.
Effect of attachment site on stability of cleavable antibody drug conjugates.
Bioconjug Chem
; 26(4): 650-9, 2015 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25643134
5.
Characterization of proprotein convertase subtilisin/kexin type 9 (PCSK9) trafficking reveals a novel lysosomal targeting mechanism via amyloid precursor-like protein 2 (APLP2).
J Biol Chem
; 288(15): 10805-18, 2013 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-23430252
6.
Mass spectrometric characterization of transglutaminase based site-specific antibody-drug conjugates.
Bioconjug Chem
; 25(2): 240-50, 2014 Feb 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-24359082
7.
Tanezumab for the treatment of pain from osteoarthritis of the knee.
N Engl J Med
; 363(16): 1521-31, 2010 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-20942668
8.
Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates.
J Pharmacol Exp Ther
; 340(2): 228-36, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22019884
9.
Antagonism of nerve growth factor-TrkA signaling and the relief of pain.
Anesthesiology
; 115(1): 189-204, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21602663
10.
Optimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates.
Sci Rep
; 9(1): 2443, 2019 02 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-30792442
11.
RN765C, a low affinity EGFR antibody drug conjugate with potent anti-tumor activity in preclinical solid tumor models.
Oncotarget
; 9(71): 33446-33458, 2018 Sep 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30323890
12.
The effects of single- and multiple-dose administration of bococizumab (RN316/PF-04950615), a humanized IgG2Δa monoclonal antibody binding proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects treated with and without atorvastatin: Results from four phase I studies.
Cardiovasc Ther
; 36(1)2018 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-29078037
13.
First-in-human randomized clinical trials of the safety and efficacy of tanezumab for treatment of chronic knee osteoarthritis pain or acute bunionectomy pain.
Pain Rep
; 3(3): e653, 2018 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-29922745
14.
Novel class of pain drugs based on antagonism of NGF.
Trends Pharmacol Sci
; 27(2): 85-91, 2006 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-16376998
15.
A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone.
Cancer Res
; 65(20): 9426-35, 2005 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16230406
16.
Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design.
Mol Cancer Ther
; 15(5): 958-70, 2016 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-26944918
17.
Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis.
Pain
; 116(1-2): 8-16, 2005 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-15927377
18.
Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization.
Pain
; 115(1-2): 128-41, 2005 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-15836976
19.
Common Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Epitopes Mediate Multiple Routes for Internalization and Function.
PLoS One
; 10(4): e0125127, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25905719
20.
Precise and efficient antibody epitope determination through library design, yeast display and next-generation sequencing.
J Mol Biol
; 427(6 Pt B): 1513-1534, 2015 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-25284753