Detalles de la búsqueda
1.
Monomethyl Auristatin E (MMAE), a Payload for Multiple Antibody Drug Conjugates (ADCs), Demonstrates Differential Red Blood Cell Partitioning Across Human and Animal Species.
Xenobiotica
; : 1-13, 2024 Apr 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-38647387
2.
Trastuzumab does not bind rat or mouse ErbB2/neu: implications for selection of non-clinical safety models for trastuzumab-based therapeutics.
Breast Cancer Res Treat
; 191(2): 303-317, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-34708303
3.
Personalized Cancer Vaccines: Clinical Landscape, Challenges, and Opportunities.
Mol Ther
; 29(2): 555-570, 2021 02 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33038322
4.
Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuropathy.
Toxicol Appl Pharmacol
; 421: 115534, 2021 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33852878
5.
Anti-Lymphocyte Antigen 6 Complex, Locus E-Seco-Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals.
Drug Metab Dispos
; 48(12): 1247-1256, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33020064
6.
Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti-Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats.
Drug Metab Dispos
; 48(11): 1161-1168, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32839277
7.
Peripheral neuropathy with microtubule inhibitor containing antibody drug conjugates: Challenges and perspectives in translatability from nonclinical toxicology studies to the clinic.
Regul Toxicol Pharmacol
; 82: 1-13, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27773754
8.
Clinical pharmacology strategies to accelerate the development of polatuzumab vedotin and summary of key findings.
Adv Drug Deliv Rev
; 207: 115193, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38311111
9.
Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFß3 Antibody for the Treatment of Fibrotic Diseases.
J Pharm Sci
; 112(11): 2910-2920, 2023 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-37429356
10.
A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides.
Chem Sci
; 13(11): 3147-3160, 2022 Mar 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-35414872
11.
Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats.
Bioconjug Chem
; 22(10): 1994-2004, 2011 Oct 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-21913715
12.
Preclinical Characterization of the Distribution, Catabolism, and Elimination of a Polatuzumab Vedotin-Piiq (POLIVY®) Antibody-Drug Conjugate in Sprague Dawley Rats.
J Clin Med
; 10(6)2021 Mar 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-33806916
13.
Effect of immune complex formation on the distribution of a novel antibody to the ovarian tumor antigen CA125.
Drug Metab Dispos
; 38(12): 2309-19, 2010 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-20823292
14.
In vivo activity of novel capecitabine regimens alone and with bevacizumab and oxaliplatin in colorectal cancer xenograft models.
Mol Cancer Ther
; 8(1): 75-82, 2009 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19139115
15.
Complex formation of anti-VEGF-C with VEGF-C released during blood coagulation resulted in an artifact in its serum pharmacokinetics.
Pharmacol Res Perspect
; 8(2): e00573, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32125783
16.
Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells.
Mol Cancer Ther
; 17(7): 1441-1453, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29695635
17.
Preclinical pharmacokinetics and pharmacodynamics of DCLL9718A: An antibody-drug conjugate for the treatment of acute myeloid leukemia.
MAbs
; 10(8): 1312-1321, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30183491
18.
Non-Clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats.
Drug Metab Lett
; 9(2): 119-31, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26031461
19.
Bioanalytical approaches for characterizing catabolism of antibody-drug conjugates.
Bioanalysis
; 7(13): 1583-604, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26226309
20.
Physiologically based pharmacokinetic modeling as a tool to predict drug interactions for antibody-drug conjugates.
Clin Pharmacokinet
; 54(1): 81-93, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25223698