Detalles de la búsqueda
1.
Di-indenopyridines as topoisomerase II-selective anticancer agents: Design, synthesis, and structure-activity relationships.
Bioorg Med Chem
; 91: 117403, 2023 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37418826
2.
Potent inhibitory activity of hydroxylated 2-benzylidene-3,4-dihydronaphthalen-1(2H)-ones on LPS-stimulated reactive oxygen species production in RAW 264.7 macrophages.
Bioorg Med Chem Lett
; 73: 128921, 2022 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35932905
3.
Synthesis and structure-activity relationships of hydroxylated and halogenated 2,4-diaryl benzofuro[3,2-b]pyridin-7-ols as selective topoisomerase IIα inhibitors.
Bioorg Chem
; 111: 104884, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33872925
4.
Antioxidative and anti-inflammatory activity of psiguadial B and its halogenated analogues as potential neuroprotective agents.
Bioorg Chem
; 113: 105027, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34098398
5.
AK-I-190, a New Catalytic Inhibitor of Topoisomerase II with Anti-Proliferative and Pro-Apoptotic Activity on Androgen-Negative Prostate Cancer Cells.
Int J Mol Sci
; 22(20)2021 Oct 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34681904
6.
Introduction of amino moiety enhances the inhibitory potency of 1-tetralone chalcone derivatives against LPS-stimulated reactive oxygen species production in RAW 264.7 macrophages.
Bioorg Chem
; 87: 495-505, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30927590
7.
Identification of sulfonyl-loxoprofen as novel phase 2 conjugate in rat.
Biopharm Drug Dispos
; 40(7): 234-241, 2019 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-31242324
8.
Design, synthesis, and structure-activity relationships of new benzofuro[3,2-b]pyridin-7-ols as DNA topoisomerase II inhibitors.
Bioorg Med Chem Lett
; 28(4): 566-571, 2018 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29402741
9.
Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease.
Bioorg Med Chem Lett
; 28(14): 2436-2441, 2018 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29910080
10.
A new phenolic series of indenopyridinone as topoisomerase inhibitors: Design, synthesis, and structure-activity relationships.
Bioorg Med Chem
; 26(18): 5212-5223, 2018 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30262132
11.
Synthesis and SAR study of new hydroxy and chloro-substituted 2,4-diphenyl 5H-chromeno[4,3-b]pyridines as selective topoisomerase IIα-targeting anticancer agents.
Bioorg Med Chem
; 26(8): 1909-1919, 2018 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29510948
12.
Design, synthesis, biological evaluation, structure-activity relationship study, and mode of action of 2-phenol-4,6-dichlorophenyl-pyridines.
Bioorg Chem
; 79: 1-18, 2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29715635
13.
Inhibition of LPS-stimulated ROS production by fluorinated and hydroxylated chalcones in RAW 264.7 macrophages with structure-activity relationship study.
Bioorg Med Chem Lett
; 27(5): 1205-1209, 2017 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28159411
14.
2-Chlorophenyl-substituted benzofuro[3,2-b]pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent.
Bioorg Med Chem Lett
; 27(15): 3279-3283, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28633898
15.
Effect of chlorine substituent on cytotoxic activities: Design and synthesis of systematically modified 2,4-diphenyl-5H-indeno[1,2-b]pyridines.
Bioorg Med Chem Lett
; 26(7): 1726-31, 2016 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26927425
16.
Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents.
Bioorg Chem
; 66: 145-59, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27174797
17.
Topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines.
Bioorg Med Chem
; 23(13): 3638-54, 2015 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25936262
18.
Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines.
Bioorg Med Chem
; 23(13): 3499-512, 2015 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26022080
19.
Design and synthesis of conformationally constrained hydroxylated 4-phenyl-2-aryl chromenopyridines as novel and selective topoisomerase II-targeted antiproliferative agents.
Bioorg Med Chem
; 23(19): 6454-66, 2015 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26361737
20.
Identification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitors.
Eur J Med Chem
; 227: 113916, 2022 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34678573