Detalles de la búsqueda
1.
Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid.
Drug Metab Dispos
; 50(8): 1077-1086, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35636769
2.
Absence of OATP1B (Organic Anion-Transporting Polypeptide) Induction by Rifampin in Cynomolgus Monkeys: Determination Using the Endogenous OATP1B Marker Coproporphyrin and Tissue Gene Expression.
J Pharmacol Exp Ther
; 375(1): 139-151, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32719071
3.
Tricyclic sulfones as potent, selective and efficacious RORγt inverse agonists - Exploring C6 and C8 SAR using late-stage functionalization.
Bioorg Med Chem Lett
; 30(23): 127521, 2020 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32882417
4.
Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1).
Bioorg Med Chem Lett
; 26(10): 2470-2474, 2016 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27055941
5.
Dual Inhibition of Interleukin-23 and Interleukin-17 Offers Superior Efficacy in Mouse Models of Autoimmunity.
J Pharmacol Exp Ther
; 354(2): 152-65, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26015463
6.
An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis.
J Immunol
; 184(7): 3917-26, 2010 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20190141
7.
Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors.
Bioorg Med Chem Lett
; 21(15): 4633-7, 2011 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21705217
8.
Quantification of surrogate monoclonal antibodies in mouse serum using LC-MS/MS.
Bioanalysis
; 13(3): 147-159, 2021 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-33543654
9.
Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis.
ACS Med Chem Lett
; 12(5): 827-835, 2021 May 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34055233
10.
Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313.
J Med Chem
; 64(5): 2714-2724, 2021 03 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33591748
11.
Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach.
ACS Med Chem Lett
; 11(12): 2510-2518, 2020 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33335675
12.
Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.
J Med Chem
; 63(23): 15050-15071, 2020 12 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33261314
13.
Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists.
ACS Med Chem Lett
; 10(3): 367-373, 2019 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30891142
14.
Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt-Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy.
J Med Chem
; 62(21): 9931-9946, 2019 11 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31638797
15.
Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors.
J Med Chem
; 51(1): 4-16, 2008 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-18072718
16.
Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38 alpha MAP kinase inhibitors.
Bioorg Med Chem Lett
; 18(8): 2739-44, 2008 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18364256
17.
The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor.
Bioorg Med Chem Lett
; 18(6): 1762-7, 2008 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18313298
18.
Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).
J Med Chem
; 50(15): 3730-42, 2007 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-17585753
19.
2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor.
J Med Chem
; 49(23): 6819-32, 2006 Nov 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-17154512
20.
Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series.
J Med Chem
; 59(6): 2820-40, 2016 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26924461