Detalles de la búsqueda
1.
The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury.
Int J Mol Sci
; 24(11)2023 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37298645
2.
Applications of Quantitative Systems Pharmacology (QSP) in Drug Development for NAFLD and NASH and Its Regulatory Application.
Pharm Res
; 39(8): 1789-1802, 2022 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-35610402
3.
Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling.
Pharm Res
; 36(3): 48, 2019 Feb 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30734107
4.
Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury.
Biopharm Drug Dispos
; 35(1): 33-49, 2014 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-24214486
5.
Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH).
Clin Pharmacol Ther
; 113(2): 275-297, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35429164
6.
An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury.
J Pharmacol Exp Ther
; 342(2): 529-40, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22593093
7.
In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI.
J Pharmacokinet Pharmacodyn
; 39(5): 527-41, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22875368
8.
Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling.
Toxicol Sci
; 188(1): 108-116, 2022 06 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-35556143
9.
Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition.
Front Pharmacol
; 13: 1085621, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36733378
10.
Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury.
Toxicol Sci
; 167(2): 458-467, 2019 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30289550
11.
Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity.
Pharmacol Res Perspect
; 7(6): e00523, 2019 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31624633
12.
Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity.
Toxicol Sci
; 166(1): 123-130, 2018 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30060248
13.
Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling.
Clin Transl Sci
; 11(5): 498-505, 2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29877622
14.
The role of quantitative systems pharmacology modeling in the prediction and explanation of idiosyncratic drug-induced liver injury.
Drug Metab Pharmacokinet
; 32(1): 40-45, 2017 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-28129975
15.
Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses.
Gene Regul Syst Bio
; 11: 1177625017696074, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28615926
16.
Dose-response in a high density three-dimensional liver device with real-time bioenergetic and metabolic flux quantification.
Toxicol In Vitro
; 45(Pt 1): 119-127, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-28867505
17.
Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.
Toxicol Sci
; 155(1): 61-74, 2017 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27655350
18.
Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury.
J Pharm Sci
; 105(2): 443-459, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26869411
19.
Use of a systems model of drug-induced liver injury (DILIsym(®)) to elucidate the mechanistic differences between acetaminophen and its less-toxic isomer, AMAP, in mice.
Toxicol Lett
; 226(2): 163-72, 2014 Apr 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-24560604
20.
Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury.
Front Pharmacol
; 5: 240, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25426072