Detalles de la búsqueda
1.
Methyl-substitution of an iminohydantoin spiropiperidine ß-secretase (BACE-1) inhibitor has a profound effect on its potency.
Bioorg Med Chem Lett
; 25(21): 4812-4819, 2015 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26195137
2.
Evaluation of plasma proteomic data for Alzheimer disease state classification and for the prediction of progression from mild cognitive impairment to Alzheimer disease.
Alzheimer Dis Assoc Disord
; 27(3): 233-43, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23023094
3.
Characterization of plasma ß-secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease.
J Neurosci Res
; 90(12): 2247-58, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22987781
4.
Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound.
J Neurosci
; 30(19): 6743-50, 2010 May 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-20463236
5.
Decrease in brain soluble amyloid precursor protein ß (sAPPß) in Alzheimer's disease cortex.
J Neurosci Res
; 89(6): 822-32, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21433051
6.
Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers.
Ann Neurol
; 68(2): 220-30, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20641005
7.
Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI.
Acta Neuropathol
; 121(5): 597-609, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21311900
8.
Modeling effect of a γ-secretase inhibitor on amyloid-ß dynamics reveals significant role of an amyloid clearance mechanism.
Bull Math Biol
; 73(1): 230-47, 2011 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-20411345
9.
Application of an end-to-end biomarker discovery platform to identify target engagement markers in cerebrospinal fluid by high resolution differential mass spectrometry.
J Proteome Res
; 9(3): 1392-401, 2010 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-20095649
10.
SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition.
Bioorg Med Chem Lett
; 20(6): 1885-9, 2010 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20176482
11.
Regulation of gene expression by lithium and depletion of inositol in slices of adult rat cortex.
Neuron
; 45(6): 861-72, 2005 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15797548
12.
First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.
J Pharmacol Exp Ther
; 328(1): 131-40, 2009 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-18854490
13.
Effects of Exercise on EEG Activity and Standard Tools Used to Assess Concussion.
J Healthc Eng
; 2019: 4794637, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31183030
14.
In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
J Pharmacol Exp Ther
; 324(3): 957-69, 2008 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-18156464
15.
Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloid.
J Med Chem
; 50(15): 3431-3, 2007 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-17583334
16.
Macrocyclic inhibitors of beta-secretase: functional activity in an animal model.
J Med Chem
; 49(21): 6147-50, 2006 Oct 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-17034118
17.
Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1).
J Med Chem
; 49(25): 7270-3, 2006 Dec 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-17149856
18.
Exploration of EEG features of Alzheimer's disease using continuous wavelet transform.
Med Biol Eng Comput
; 53(9): 843-55, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-25863694
19.
Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).
J Med Chem
; 47(26): 6447-50, 2004 Dec 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-15588077
20.
Identification of resting and active state EEG features of Alzheimer's disease using discrete wavelet transform.
Ann Biomed Eng
; 41(6): 1243-57, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23536113