Detalles de la búsqueda
1.
Commentary: Value of information case study strongly supports use of the Threshold of Toxicological Concern (TTC).
Regul Toxicol Pharmacol
; 149: 105594, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38555099
2.
Species differences in specific ligand-binding affinity and activation of AHR: The biological basis for calculation of relative effective potencies and toxic equivalence factors.
Regul Toxicol Pharmacol
; 149: 105598, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38548044
3.
Letter to the Editor: Modeling the changing face of Phosphatidylethanol's window of detection.
Regul Toxicol Pharmacol
; 146: 105537, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-38052393
4.
The 2022 revised WHO TEFs for dioxins and dioxin-like chemicals: The importance of considering the use of species-specific information to determine relative effective potency for human-based risk assessment.
Regul Toxicol Pharmacol
; 149: 105599, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38490576
5.
Providing context for phosphatidylethanol as a biomarker of alcohol consumption with a pharmacokinetic model.
Regul Toxicol Pharmacol
; 94: 163-171, 2018 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-29408287
6.
How well can carcinogenicity be predicted by high throughput "characteristics of carcinogens" mechanistic data?
Regul Toxicol Pharmacol
; 90: 185-196, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-28866267
7.
Bayesian methods for uncertainty factor application for derivation of reference values.
Regul Toxicol Pharmacol
; 80: 9-24, 2016 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-27211295
8.
The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor.
Regul Toxicol Pharmacol
; 73(1): 172-90, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26145830
9.
An exposure:activity profiling method for interpreting high-throughput screening data for estrogenic activity--proof of concept.
Regul Toxicol Pharmacol
; 71(3): 398-408, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25656492
10.
Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes.
Regul Toxicol Pharmacol
; 71(3): 463-77, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25707856
11.
The use of mode of action information in risk assessment: quantitative key events/dose-response framework for modeling the dose-response for key events.
Crit Rev Toxicol
; 44 Suppl 3: 17-43, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-25070415
12.
Use and validation of HT/HC assays to support 21st century toxicity evaluations.
Regul Toxicol Pharmacol
; 65(2): 259-68, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23291301
13.
Utilizing Threshold of Toxicological Concern (TTC) with High Throughput Exposure Predictions (HTE) as a Risk-Based Prioritization Approach for thousands of chemicals.
Comput Toxicol
; 7: 58-67, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-31338483
14.
In vitro to in vivo extrapolation for high throughput prioritization and decision making.
Toxicol In Vitro
; 47: 213-227, 2018 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-29203341
15.
Approaches for describing and communicating overall uncertainty in toxicity characterizations: U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) as a case study.
Environ Int
; 89-90: 110-28, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26827183
16.
A model for aryl hydrocarbon receptor-activated gene expression shows potency and efficacy changes and predicts squelching due to competition for transcription co-activators.
PLoS One
; 10(6): e0127952, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26039703
17.
Evidence-based toxicology for the 21st century: opportunities and challenges.
ALTEX
; 30(1): 74-103, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23338808
18.
Just who is at risk? The ethics of environmental regulation.
Hum Exp Toxicol
; 30(8): 795-819, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20670991
19.
Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran.
Toxicol Sci
; 118(1): 224-35, 2010 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-20705892
20.
Estimates of cancer potency of 2,3,7,8-tetrachlorodibenzo(p)dioxin using linear and nonlinear dose-response modeling and toxicokinetics.
Toxicol Sci
; 112(2): 490-506, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19776211