Detalles de la búsqueda
1.
Characterization of potential degradation products of brexpiprazole by liquid chromatography/quadrupole-time-of-flight mass spectrometry and nuclear magnetic resonance, and prediction of their physicochemical properties by ADMET Predictor™.
Rapid Commun Mass Spectrom
; 37(1): e9415, 2023 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36226712
2.
Exploration of the Plausible Mechanism of Ethambutol Induced Ocular Toxicity by Using Proteomics Informed Physiologically Based Pharmacokinetic (PBPK) Modeling.
Pharm Res
; 39(4): 677-689, 2022 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-35301670
3.
Comparative Proteomics Analysis of the Postmitochondrial Supernatant Fraction of Human Lens-Free Whole Eye and Liver.
Drug Metab Dispos
; 49(7): 592-600, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33952609
4.
PBPK Analysis to Study the Impact of Genetic Polymorphism of NAT2 on Drug-Drug Interaction Potential of Isoniazid.
Pharm Res
; 38(9): 1485-1496, 2021 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-34518943
5.
Structure-Based Virtual Screening to Discover Potential Lead Molecules for the SARS-CoV-2 Main Protease.
J Chem Inf Model
; 60(12): 5781-5793, 2020 12 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-32687345
6.
Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.
Drug Metab Dispos
; 47(8): 818-831, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31101678
7.
Identification of novel glutathione conjugates of terbinafine in liver microsomes and hepatocytes across species.
Xenobiotica
; 49(12): 1403-1413, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-30747549
8.
Characterization of stress degradation products of amodiaquine dihydrochloride by liquid chromatography with high-resolution mass spectrometry and prediction of their properties by using ADMET Predictor™.
J Sep Sci
; 40(23): 4530-4540, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-28985017
9.
Detection of glutathione conjugates of amiodarone and its reactive diquinone metabolites in rat bile using mass spectrometry tools.
Rapid Commun Mass Spectrom
; 30(10): 1242-1248, 2016 05 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-28328020
10.
Quantitation of memantine hydrochloride bulk drug and its tablet formulation using proton nuclear magnetic resonance spectrometry.
Magn Reson Chem
; 54(8): 632-6, 2016 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26923624
11.
Study of the forced degradation behavior of prasugrel hydrochloride by liquid chromatography with mass spectrometry and liquid chromatography with NMR detection and prediction of the toxicity of the characterized degradation products.
J Sep Sci
; 38(17): 2995-3005, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-26114771
12.
Metabolite identification studies on amiodarone in in vitro (rat liver microsomes, rat and human liver S9 fractions) and in vivo (rat feces, urine, plasma) matrices by using liquid chromatography with high-resolution mass spectrometry and multiple-stage mass spectrometry: characterization of the diquinone metabolite supposedly responsible for the drug's hepatotoxicity.
Rapid Commun Mass Spectrom
; 28(4): 311-31, 2014 Feb 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-24395499
13.
Practical and economical implementation of online H/D exchange in LC-MS.
Anal Chem
; 85(22): 10904-12, 2013 Nov 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-24117319
14.
LC-MS/TOF, LC-MSn, on-line H/D exchange and LC-NMR studies on rosuvastatin degradation and in silico determination of toxicity of its degradation products: a comprehensive approach during drug development.
Anal Bioanal Chem
; 405(10): 3215-31, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23386001
15.
Effect of counterion on the solid state photodegradation behavior of prazosin salts.
AAPS PharmSciTech
; 14(2): 757-63, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23595416
16.
Stress degradation study on entrectinib and characterization of its degradation products using HRMS and NMR.
J Pharm Biomed Anal
; 208: 114459, 2022 Jan 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-34768159
17.
Characterization of stress degradation products of nintedanib by UPLC, UHPLC-Q-TOF/MS/MS and NMR: Evidence of a degradation product with a structure alert for mutagenicity.
J Pharm Biomed Anal
; 199: 114037, 2021 May 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-33836462
18.
Exploration of inhibition potential of isoniazid and its metabolites towards CYP2E1 in human liver microsomes through LC-MS/MS analysis.
J Pharm Biomed Anal
; 203: 114223, 2021 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34214766
19.
Characterization of degradation products of celiprolol hydrochloride using hyphenated mass and NMR techniques.
J Pharm Biomed Anal
; 197: 113953, 2021 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33618130
20.
Influence of microenvironment pH, humidity, and temperature on the stability of polymorphic and amorphous forms of clopidogrel bisulfate.
AAPS PharmSciTech
; 11(1): 197-203, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-20112136