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1.
Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 9-oxo-9H-fluorene ring.
Bioorg Med Chem Lett
; 20(3): 1288-92, 2010 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20034792
2.
Discovery of N-methyl-4-(4-methoxyanilino)quinazolines as potent apoptosis inducers. Structure-activity relationship of the quinazoline ring.
Bioorg Med Chem Lett
; 20(7): 2330-4, 2010 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20188546
3.
Discovery of 4-anilino-N-methylthieno[3,2-d]pyrimidines and 4-anilino-N-methylthieno[2,3-d]pyrimidines as potent apoptosis inducers.
Bioorg Med Chem Lett
; 19(13): 3536-40, 2009 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19464890
4.
Discovery of substituted N'-(2-oxoindolin-3-ylidene)benzohydrazides as new apoptosis inducers using a cell- and caspase-based HTS assay.
Bioorg Med Chem Lett
; 19(10): 2710-3, 2009 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19369076
5.
Discovery of substituted 4-anilino-2-arylpyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 2. Structure-activity relationships of the 2-aryl group.
Bioorg Med Chem Lett
; 19(8): 2305-9, 2009 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19285392
6.
Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the carboxamide group.
Bioorg Med Chem Lett
; 19(11): 3045-9, 2009 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19394823
7.
Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2: Structure-activity relationships of the 4-, 5-, 6-, 7- and 8-positions.
Bioorg Med Chem Lett
; 19(13): 3481-4, 2009 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19467598
8.
MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps.
Cancer Res
; 67(12): 5865-71, 2007 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17575155
9.
Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. Part 1: Structure-activity relationships of the 1- and 3-positions.
Bioorg Med Chem Lett
; 18(23): 6259-64, 2008 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18952423
10.
Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration.
J Med Chem
; 52(8): 2341-51, 2009 Apr 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-19296653
11.
Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity.
J Med Chem
; 51(15): 4771-9, 2008 Aug 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-18651728
12.
Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: structure-activity relationships of the 4-anilino group.
Bioorg Med Chem
; 14(23): 7761-73, 2006 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16919962
13.
A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid.
Proc Natl Acad Sci U S A
; 102(34): 12095-100, 2005 Aug 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-16103367
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