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1.
A critical review of the effectiveness of rodent pharmaceutical carcinogenesis testing in predicting for human risk.
Vet Pathol
; 48(3): 772-84, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21383116
2.
An evaluation of chronic 6- and 12-month rat toxicology studies as predictors of 2-year tumor outcome.
Vet Pathol
; 47(4): 614-29, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20516294
3.
The use of in situ perfusion of the rat mesentery as a model to investigate vascular injury directly induced by drugs.
Methods Find Exp Clin Pharmacol
; 32(7): 489-97, 2010 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21069100
4.
Preclinical predictors of clinical safety: opportunities for improvement.
Clin Pharmacol Ther
; 82(2): 210-4, 2007 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-17507920
5.
Differential modulation of gene induction by glucocorticoids and antiglucocorticoids in rat hepatoma tissue culture cells.
Cancer Res
; 49(8 Suppl): 2244s-2252s, 1989 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-2564808
6.
Mechanism of dexamethasone 21-mesylate antiglucocorticoid action: I. Receptor-antiglucocorticoid complexes do not competitively inhibit receptor-glucocorticoid complex activation of gene transcription in vivo.
Mol Endocrinol
; 1(9): 648-58, 1987 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-3153481
7.
Mechanism of dexamethasone 21-mesylate antiglucocorticoid action: II. Receptor-antiglucocorticoid complexes do not interact productively with mouse mammary tumor virus long terminal repeat chromatin.
Mol Endocrinol
; 1(9): 659-65, 1987 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-2856414
8.
P2 purinergic receptors potentiate parathyroid hormone receptor-mediated increases in intracellular calcium and inositol trisphosphate in UMR-106 rat osteoblasts.
Endocrinology
; 136(10): 4489-97, 1995 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-7664669
9.
Distribution of P2Y receptor subtypes on haematopoietic cells.
Br J Pharmacol
; 123(5): 789-94, 1998 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-9535005
10.
Evaluation of in vitro reporter gene induction assays for use in a rapid prescreen for compound selection to test specificity in the Tg.AC mouse short-term carcinogenicity assay.
Toxicol Sci
; 57(1): 43-53, 2000 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-10966510
11.
Transgenic tumor models for carcinogen identification: the heterozygous Trp53-deficient and RasH2 mouse lines.
Mutat Res
; 540(2): 165-76, 2003 Oct 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-14550500
12.
Gene expression profiles and genetic damage in benzo(a)pyrene diol epoxide-exposed TK6 cells.
Mutat Res
; 549(1-2): 43-64, 2004 May 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-15120962
13.
Transgenic animal models that might be useful in identifying unsuspected oncogenic factors in tumour cell substrates.
Dev Biol (Basel)
; 106: 123-31; discussion 131-2, 143-60, 2001.
Artículo
en Inglés
| MEDLINE | ID: mdl-11761226
14.
The utility of the K6/ODC transgenic mouse as an alternative short term dermal model for carcinogenicity testing of pharmaceuticals.
Regul Toxicol Pharmacol
; 50(1): 87-97, 2008 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-18069108
15.
A systematic approach to preclinical and clinical safety biomarker qualification incorporating Bradford Hill's principles of causality association.
Clin Pharmacol Ther
; 88(2): 260-2, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20592723
16.
K562 leukemia cells express P2T (adenosine diphosphate) purinergic receptors.
J Pharmacol Exp Ther
; 261(2): 580-5, 1992 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-1578375
17.
Acute stimulation by glucocorticoids of gluconeogenesis from lactate/pyruvate in isolated hepatocytes from normal and adrenalectomized rats.
J Biol Chem
; 260(23): 12754-60, 1985 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-3876337
18.
The interaction between the cytosolic pyridine nucleotide redox potential and gluconeogenesis from lactate/pyruvate in isolated rat hepatocytes. Implications for investigations of hormone action.
J Biol Chem
; 260(23): 12748-53, 1985 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-4044607
19.
Estimation of the relative contributions of enhanced production of oxalacetate and inhibition of pyruvate kinase to acute hormonal stimulation of gluconeogenesis in rat hepatocytes. An analysis of the effects of glucagon, angiotensin II, and dexamethasone on gluconeogenic flux from lactate/pyruvate.
J Biol Chem
; 260(23): 12761-8, 1985 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-4044608
20.
Evidence for separate calcium-signaling P2T and P2U purinoceptors in human megakaryocytic Dami cells.
Blood
; 83(5): 1258-67, 1994 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-8118030