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1.
Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.
J Med Chem
; 51(14): 4239-52, 2008 Jul 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-18578472
2.
Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP.
Bioorg Med Chem Lett
; 17(20): 5671-6, 2007 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17804233
3.
Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.
Bioorg Med Chem Lett
; 16(12): 3175-9, 2006 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16603356
4.
Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility.
Bioorg Med Chem Lett
; 16(7): 1780-3, 2006 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16439122
5.
Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme.
Chem Res Toxicol
; 18(9): 1427-37, 2005 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-16167835
6.
Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor.
Drug Metab Dispos
; 31(11): 1352-60, 2003 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-14570767
7.
Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective I(Ks)-blocking class III antiarrhythmic agents.
Bioorg Med Chem Lett
; 13(6): 1165-8, 2003 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-12643935
8.
Metabolism of rofecoxib in vitro using human liver subcellular fractions.
Drug Metab Dispos
; 31(11): 1398-408, 2003 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-14570773
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