Detalles de la búsqueda
1.
Rational design of a new antibiotic class for drug-resistant infections.
Nature
; 597(7878): 698-702, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34526714
2.
Rapid in vitro activity of telavancin against Bacillus anthracis and in vivo protection against inhalation anthrax infection in the rabbit model.
Antimicrob Agents Chemother
; : e0011224, 2024 Jun 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-38888319
3.
Discovery of a novel type IIb RelBE toxin-antitoxin system in Mycobacterium tuberculosis defined by co-regulation with an antisense RNA.
Mol Microbiol
; 117(6): 1419-1433, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35526138
4.
New Investigations with Lupane Type A-Ring Azepane Triterpenoids for Antimycobacterial Drug Candidate Design.
Int J Mol Sci
; 22(22)2021 Nov 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-34830423
5.
Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.
Biochemistry
; 56(13): 1865-1878, 2017 04 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-28225601
6.
Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors.
J Am Chem Soc
; 139(9): 3417-3429, 2017 03 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28151657
7.
Thermal and Photoinduced Copper-Promoted C-Se Bond Formation: Synthesis of 2-Alkyl-1,2-benzisoselenazol-3(2H)-ones and Evaluation against Mycobacterium tuberculosis.
J Org Chem
; 82(7): 3844-3854, 2017 04 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28273423
8.
Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosis.
Org Biomol Chem
; 14(25): 6119-6133, 2016 Jul 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27251120
9.
Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor.
J Biol Chem
; 289(23): 15987-6005, 2014 Jun 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-24739388
10.
Cell division inhibitors with efficacy equivalent to isoniazid in the acute murine Mycobacterium tuberculosis infection model.
J Antimicrob Chemother
; 70(11): 3070-3, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26245639
11.
The Burkholderia pseudomallei enoyl-acyl carrier protein reductase FabI1 is essential for in vivo growth and is the target of a novel chemotherapeutic with efficacy.
Antimicrob Agents Chemother
; 58(2): 931-5, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24277048
12.
Substituted diphenyl ethers as a novel chemotherapeutic platform against Burkholderia pseudomallei.
Antimicrob Agents Chemother
; 58(3): 1646-51, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24379198
13.
Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents.
Bioorg Med Chem
; 22(9): 2602-12, 2014 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24726304
14.
Neuroprotective Efficacy of the Glucocorticoid Receptor Modulator PT150 in the Rotenone Mouse Model of Parkinson's Disease.
bioRxiv
; 2024 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38659796
15.
Targeting intracellular nontuberculous mycobacteria and M. tuberculosis with a bactericidal enzymatic cocktail.
Microbiol Spectr
; 12(5): e0353423, 2024 May 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38534149
16.
The Francisella tularensis FabI enoyl-acyl carrier protein reductase gene is essential to bacterial viability and is expressed during infection.
J Bacteriol
; 195(2): 351-8, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23144254
17.
Iterative feature removal yields highly discriminative pathways.
BMC Genomics
; 14: 832, 2013 Nov 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-24274115
18.
MazF6 toxin of Mycobacterium tuberculosis demonstrates antitoxin specificity and is coupled to regulation of cell growth by a Soj-like protein.
BMC Microbiol
; 13: 240, 2013 Oct 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-24172039
19.
Benzimidazole-based antibacterial agents against Francisella tularensis.
Bioorg Med Chem
; 21(11): 3318-26, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23623254
20.
Epetraborole, a leucyl-tRNA synthetase inhibitor, demonstrates murine efficacy, enhancing the in vivo activity of ceftazidime against Burkholderia pseudomallei, the causative agent of melioidosis.
PLoS Negl Trop Dis
; 17(11): e0011795, 2023 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-38011278