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1.
Pro-cathepsin D interacts with the extracellular domain of the beta chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth.
J Cell Sci
; 123(Pt 19): 3336-46, 2010 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20826454
2.
Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups.
Bioorg Med Chem Lett
; 22(24): 7351-6, 2012 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23142614
3.
Synthesis and SAR of acyclic HCV NS3 protease inhibitors with novel P4-benzoxaborole moieties.
Bioorg Med Chem Lett
; 21(7): 2048-54, 2011 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21353550
4.
Synthesis of new acylsulfamoyl benzoxaboroles as potent inhibitors of HCV NS3 protease.
Bioorg Med Chem Lett
; 20(24): 7493-7, 2010 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21041080
5.
Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease.
Bioorg Med Chem Lett
; 20(24): 7317-22, 2010 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21067923
6.
Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates.
Bioorg Med Chem Lett
; 20(19): 5695-700, 2010 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20801653
7.
Synthesis and evaluation of novel alpha-amino cyclic boronates as inhibitors of HCV NS3 protease.
Bioorg Med Chem Lett
; 20(12): 3550-6, 2010 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20493689
8.
Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors.
J Med Chem
; 50(1): 6-9, 2007 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-17201405
9.
Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity.
J Med Chem
; 50(1): 2-5, 2007 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-17201404
10.
Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper.
Mol Biol Cell
; 14(10): 4162-72, 2003 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-14517326
11.
Expression, purification, and characterization of an enzymatically active truncated human rho-kinase I (ROCK I) domain expressed in Sf-9 insect cells.
Protein Pept Lett
; 13(4): 369-76, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16712513
12.
Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.
J Med Chem
; 57(5): 1902-13, 2014 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-23672667
13.
Discovery of novel urea-based hepatitis C protease inhibitors with high potency against protease-inhibitor-resistant mutants.
J Med Chem
; 55(7): 3021-6, 2012 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-22471376
14.
Distinct concentration-dependent effects of the polo-like kinase 1-specific inhibitor GSK461364A, including differential effect on apoptosis.
Cancer Res
; 69(17): 6969-77, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19690138
15.
Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: implications for cellular potency and selectivity over insulin receptor.
Biochem Pharmacol
; 78(12): 1438-47, 2009 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19665448
16.
Assessment of chemical coverage of kinome space and its implications for kinase drug discovery.
J Med Chem
; 51(24): 7898-914, 2008 Dec 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-19035792
17.
Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases.
J Med Chem
; 51(21): 6631-4, 2008 Nov 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-18842034
18.
Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities.
J Pharmacol Exp Ther
; 320(1): 89-98, 2007 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-17018693
19.
Expression, preparation, and high-throughput screening of caspase-8: discovery of redox-based and steroid diacid inhibition.
Arch Biochem Biophys
; 399(2): 195-205, 2002 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-11888206
20.
Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase.
J Biol Chem
; 277(43): 41128-39, 2002 Oct 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-12154098
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