Detalles de la búsqueda
1.
Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids.
Arch Toxicol
; 96(1): 195-210, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34689256
2.
Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism.
Arch Toxicol
; 95(1): 11-25, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33164107
3.
Sesquiterpenes Are Agonists of the Pregnane X Receptor but Do Not Induce the Expression of Phase I Drug-Metabolizing Enzymes in the Human Liver.
Int J Mol Sci
; 20(18)2019 Sep 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31540101
4.
Iron depletion induces hepatic secretion of biliary lipids and glutathione in rats.
Biochim Biophys Acta Mol Cell Biol Lipids
; 1862(12): 1469-1480, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-28888833
5.
Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulation.
Drug Metab Rev
; 48(2): 139-58, 2016 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27278216
6.
Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier.
Drug Metab Rev
; 46(1): 19-32, 2014 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-24020384
7.
Resveratrol as an inhibitor of pregnane X receptor (PXR): another lesson in PXR antagonism.
J Pharmacol Sci
; 126(2): 177-8, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25341568
8.
U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.
Arch Toxicol
; 88(12): 2243-59, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24819614
9.
Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell model.
EJNMMI Radiopharm Chem
; 9(1): 32, 2024 Apr 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-38637347
10.
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure.
J Med Chem
; 66(4): 2422-2456, 2023 02 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36756805
11.
Gene Expression Profiling of 1α,25(OH)2 D3 Treatment in 2D/3D Human Hepatocyte Models Reveals CYP3A4 Induction but Minor Changes in Other Xenobiotic-Metabolizing Genes.
Mol Nutr Food Res
; 66(9): e2200070, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35184385
12.
Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain.
Cells
; 9(12)2020 11 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-33255185
13.
The 3'-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids.
Acta Pharm Sin B
; 10(1): 136-152, 2020 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-31998607
14.
3ß-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3α-epimer by hepatic metabolism.
J Steroid Biochem Mol Biol
; 202: 105702, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32505574
15.
Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three-Dimensional Spheroid Cultures of Primary Human Hepatocytes.
Clin Pharmacol Ther
; 108(4): 844-855, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32320483
16.
Genetic Predispositions of Glucocorticoid Resistance and Therapeutic Outcomes in Polymyalgia Rheumatica and Giant Cell Arteritis.
J Clin Med
; 8(5)2019 Apr 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-31035618
17.
Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors.
Toxicol Lett
; 300: 81-91, 2019 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-30394306
18.
Stilbene compound trans-3,4,5,4´-tetramethoxystilbene, a potential anticancer drug, regulates constitutive androstane receptor (Car) target genes, but does not possess proliferative activity in mouse liver.
Toxicol Lett
; 313: 1-10, 2019 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31170421
19.
A feasibility study of the toxic responses of human induced pluripotent stem cell-derived hepatocytes to phytochemicals.
Toxicol In Vitro
; 52: 94-105, 2018 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-29902661
20.
Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling.
Front Pharmacol
; 9: 993, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30364229