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1.
A randomized study of the safety and pharmacokinetics of GSK3358699, a mononuclear myeloid-targeted bromodomain and extra-terminal domain inhibitor.
Br J Clin Pharmacol
; 88(5): 2140-2155, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34773923
2.
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.
Nature
; 478(7370): 529-33, 2011 Oct 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-21964340
3.
Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors.
ACS Med Chem Lett
; 14(9): 1231-1236, 2023 Sep 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-37736196
4.
Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression.
J Med Chem
; 64(16): 12200-12227, 2021 08 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-34387088
5.
Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains.
J Med Chem
; 63(11): 5816-5840, 2020 06 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32410449
6.
Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype.
J Med Chem
; 63(17): 9020-9044, 2020 09 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32787145
7.
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation.
Science
; 368(6489): 387-394, 2020 04 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-32193360
8.
Abeta(1-42) reduces synapse number and inhibits neurite outgrowth in primary cortical and hippocampal neurons: a quantitative analysis.
J Neurosci Methods
; 175(1): 96-103, 2008 Oct 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-18761375
9.
The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.
J Med Chem
; 57(19): 8111-31, 2014 Oct 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-25249180
10.
Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
J Med Chem
; 56(15): 6156-74, 2013 Aug 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-23829483
11.
MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease.
J Biol Chem
; 281(33): 23658-67, 2006 Aug 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-16774924
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