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1.
An inhibitor of NADPH oxidase-4 attenuates established pulmonary fibrosis in a rodent disease model.
Am J Respir Cell Mol Biol
; 50(1): 158-69, 2014 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23977848
2.
Application of a deuterium replacement strategy to modulate the pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a novel CRF1 antagonist.
Drug Metab Dispos
; 42(5): 954-62, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24616265
3.
1-Aminobenzotriazole modulates oral drug pharmacokinetics through cytochrome P450 inhibition and delay of gastric emptying in rats.
Drug Metab Dispos
; 42(7): 1117-24, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24727486
4.
Preclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotropin-releasing factor receptor 1 antagonist.
Xenobiotica
; 44(10): 902-12, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24697490
5.
NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo.
Cell Stem Cell
; 31(4): 554-569.e17, 2024 Apr 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-38579685
6.
Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases.
Bioorg Med Chem
; 21(21): 6582-91, 2013 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24021582
7.
Design and Synthesis of Inhibitors of the E3 Ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 as a Treatment for Lung Remodeling in Pulmonary Arterial Hypertension.
J Med Chem
; 66(12): 8130-8139, 2023 06 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-37294287
8.
Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans.
J Pharmacol Exp Ther
; 332(1): 17-25, 2010 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19779131
9.
Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes.
Drug Metab Dispos
; 37(1): 82-9, 2009 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-18832476
10.
Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 18(1): 375-9, 2008 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18061448
11.
Do We Need to Study Metabolism and Distribution in the Eye: Why, When, and Are We There Yet?
J Pharm Sci
; 106(9): 2276-2281, 2017 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28322939
12.
Correction to "Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma".
ACS Med Chem Lett
; 8(9): 987, 2017 Sep 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-28947949
13.
Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma.
ACS Med Chem Lett
; 8(5): 582-586, 2017 May 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28523115
14.
Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders.
J Med Chem
; 49(1): 35-8, 2006 Jan 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-16392789
15.
A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.
J Med Chem
; 49(8): 2600-10, 2006 Apr 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-16610803
16.
Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety.
J Med Chem
; 49(4): 1235-8, 2006 Feb 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-16480260
17.
7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models.
J Med Chem
; 48(23): 7089-92, 2005 Nov 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-16279764
18.
3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channels.
J Med Chem
; 45(9): 1887-900, 2002 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-11960500
19.
Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers.
J Med Chem
; 47(9): 2176-9, 2004 Apr 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-15084116
20.
Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.
J Med Chem
; 47(14): 3642-57, 2004 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15214791