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1.
Evaluation of ADMET Predictor in Early Discovery Drug Metabolism and Pharmacokinetics Project Work.
Drug Metab Dispos
; 50(2): 95-104, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34750195
2.
A strategy for early-risk predictions of clinical drug-drug interactions involving the GastroPlusTM DDI module for time-dependent CYP inhibitors.
Xenobiotica
; 48(4): 348-356, 2018 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-28443803
3.
The impact of solute carrier (SLC) drug uptake transporter loss in human and rat cryopreserved hepatocytes on clearance predictions.
Drug Metab Dispos
; 42(3): 469-80, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24396146
4.
The volume of distribution is an indicator of poor in vitro-in vivo extrapolation of clearance for acidic drugs in the rat.
Xenobiotica
; 43(8): 671-8, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23323549
5.
Rat poorly predicts the combined non-absorbed and presystemically metabolized fractions in the human.
Xenobiotica
; 43(7): 607-16, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23278250
6.
The utility of cold-preserved human hepatocytes in studies on cytochrome P450 induction and hepatic drug transport.
Xenobiotica
; 43(9): 785-91, 2013 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-23570537
7.
Practical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes.
Xenobiotica
; 42(9): 841-53, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22509824
8.
Plasma Nitrate and Nitrite Kinetics after Single Intake of Beetroot Juice in Adult Patients on Chronic Hemodialysis and in Healthy Volunteers: A Randomized, Single-Blind, Placebo-Controlled, Crossover Study.
Nutrients
; 14(12)2022 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35745210
9.
Confident application of a global human liver microsomal activity QSAR.
Future Med Chem
; 10(13): 1575-1588, 2018 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29953260
10.
Determination of the hepatocellularity number for human, dog, rabbit, rat and mouse livers from protein concentration measurements.
Toxicol In Vitro
; 20(8): 1582-6, 2006 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-16930941
11.
Optimizing DMPK Properties: Experiences from a Big Pharma DMPK Department.
Curr Drug Metab
; 17(3): 253-70, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26651977
12.
Characterization of the rates of testosterone metabolism to various products and of glutathione transferase and sulfotransferase activities in rat intestine and comparison to the corresponding hepatic and renal drug-metabolizing enzymes.
Chem Biol Interact
; 148(1-2): 49-56, 2004 Jun 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-15223356
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