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1.
Preclinical Pharmacology of [2-(3-Fluoro-5-Methanesulfonyl-phenoxy)Ethyl](Propyl)amine (IRL790), a Novel Dopamine Transmission Modulator for the Treatment of Motor and Psychiatric Complications in Parkinson Disease.
J Pharmacol Exp Ther
; 374(1): 113-125, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32358046
2.
A Phase 2a Trial Investigating the Safety and Tolerability of the Novel Cortical Enhancer IRL752 in Parkinson's Disease Dementia.
Mov Disord
; 35(6): 1046-1054, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32198802
3.
First-in-Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of Pirepemat, a Cortical Enhancer, in Healthy Volunteers.
Clin Pharmacol Drug Dev
; 10(12): 1485-1494, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34118179
4.
A first-in-human oral dose study of mesdopetam (IRL790) to assess its safety, tolerability, and pharmacokinetics in healthy male volunteers.
Pharmacol Res Perspect
; 9(3): e00792, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34018344
5.
Pridopidine: Overview of Pharmacology and Rationale for its Use in Huntington's Disease.
J Huntingtons Dis
; 7(1): 1-16, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29480206
6.
Safety and tolerability of IRL790 in Parkinson's disease with levodopa-induced dyskinesia-a phase 1b trial.
NPJ Parkinsons Dis
; 4: 35, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30534585
7.
In Vivo Systems Response Profiling and Multivariate Classification of CNS Active Compounds: A Structured Tool for CNS Drug Discovery.
ACS Chem Neurosci
; 8(4): 785-797, 2017 04 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-27997108
8.
The dopaminergic stabiliser ACR16 counteracts the behavioural primitivization induced by the NMDA receptor antagonist MK-801 in mice: implications for cognition.
Prog Neuropsychopharmacol Biol Psychiatry
; 28(4): 677-85, 2004 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-15276693
9.
Regiochemical Control and Suppression of Double Bond Isomerization in the Heck Arylation of 1-(Methoxycarbonyl)-2,5-dihydropyrrole.
J Org Chem
; 61(14): 4756-4763, 1996 Jul 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-11667407
10.
A novel series of 6-substituted 3-(pyrrolidin-1-ylmethyl)chromen-2-ones as selective monoamine oxidase (MAO) A inhibitors.
Eur J Med Chem
; 73: 177-86, 2014 Feb 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24393810
11.
Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines.
Eur J Med Chem
; 62: 241-55, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23353756
12.
Structure-activity relationship of 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole analogues as 5-HT(6) receptor agonists.
Eur J Med Chem
; 63: 578-88, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23542166
13.
The dopaminergic stabilizer pridopidine decreases expression of L-DOPA-induced locomotor sensitisation in the rat unilateral 6-OHDA model.
Eur J Pharmacol
; 698(1-3): 278-85, 2013 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-23127496
14.
Systematic in vivo screening of a series of 1-propyl-4-arylpiperidines against dopaminergic and serotonergic properties in rat brain: a scaffold-jumping approach.
J Med Chem
; 55(22): 9735-50, 2012 Nov 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-23043306
15.
Synthesis and evaluation of a set of para-substituted 4-phenylpiperidines and 4-phenylpiperazines as monoamine oxidase (MAO) inhibitors.
J Med Chem
; 55(7): 3242-9, 2012 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-22385498
16.
Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (huntexil, pridopidine, ACR16).
J Med Chem
; 53(6): 2510-20, 2010 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-20155917
17.
In vivo pharmacology of the dopaminergic stabilizer pridopidine.
Eur J Pharmacol
; 644(1-3): 88-95, 2010 Oct 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-20667452
18.
The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties.
Eur J Pharmacol
; 628(1-3): 19-26, 2010 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-19919834
19.
Efficacy and safety of the dopaminergic stabilizer Pridopidine (ACR16) in patients with Huntington's disease.
Clin Neuropharmacol
; 33(5): 260-4, 2010.
Artículo
en Inglés
| MEDLINE | ID: mdl-20616707
20.
2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.
Bioorg Med Chem Lett
; 15(19): 4230-4, 2005 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16055331
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