Detalles de la búsqueda
1.
Discovery and development of novel 10,12-disubstituted aloperine derivatives against HCoV-OC43 by targeting allosteric site of host TMPRSS2.
Bioorg Chem
; 147: 107317, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38583252
2.
Design, synthesis and triglyceride-lowering activity of tricyclic matrine derivatives for the intervention of non-alcoholic fatty liver disease.
Bioorg Chem
; 142: 106925, 2024 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37890213
3.
Discovery of new riminophenazine analogues as antimycobacterial agents against drug-resistant Mycobacterium tuberculosis.
Bioorg Chem
; 128: 105929, 2022 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35701239
4.
Structure-activity relationship and biological evaluation of 12 N-substituted aloperine derivatives as PD-L1 down-regulatory agents through proteasome pathway.
Bioorg Chem
; 117: 105432, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34678602
5.
Structure-activity relationship and biological evaluation of berberine derivatives as PCSK9 down-regulating agents.
Bioorg Chem
; 113: 104994, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34052738
6.
Discovery and evolution of 12N-substituted aloperine derivatives as anti-SARS-CoV-2 agents through targeting late entry stage.
Bioorg Chem
; 115: 105196, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34333425
7.
MPB, a novel berberine derivative, enhances lysosomal and bactericidal properties via TGF-ß-activated kinase 1-dependent activation of the transcription factor EB.
FASEB J
; 33(1): 1468-1481, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30161000
8.
Synthesis and antibacterial evaluation against resistant Gram-negative bacteria of monobactams bearing various substituents on oxime residue.
Bioorg Chem
; 94: 103487, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31831161
9.
Synthesis and biological evaluation of berberine derivatives as a new class of broad-spectrum antiviral agents against Coxsackievirus B.
Bioorg Chem
; 95: 103490, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31855821
10.
The novel quinolizidine derivate IMB-HDC inhibits STAT5a phosphorylation at 694 and 780 and promotes DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation.
Acta Pharmacol Sin
; 41(5): 686-697, 2020 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-31932645
11.
Structure-Activity Relationship of Aloperine Derivatives as New Anti-Liver Fibrogenic Agents.
Molecules
; 25(21)2020 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-33121156
12.
Discovery of 9O-Substituted Palmatine Derivatives as a New Class of anti-COL1A1 Agents via Repressing TGF-ß1/Smads and JAK1/STAT3 Pathways.
Molecules
; 25(4)2020 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32054011
13.
Synthesis and Structure-Activity Relationship of Palmatine Derivatives as a Novel Class of Antibacterial Agents against Helicobacter pylori.
Molecules
; 25(6)2020 Mar 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-32188132
14.
Novel cytisine derivatives exert anti-liver fibrosis effect via PI3K/Akt/Smad pathway.
Bioorg Chem
; 90: 103032, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31207450
15.
Synthesis and Biological Evaluation of Fangchinoline Derivatives as Anti-Inflammatory Agents through Inactivation of Inflammasome.
Molecules
; 24(6)2019 Mar 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-30909541
16.
12N-Substituted Matrinol Derivatives Inhibited the Expression of Fibrogenic Genes via Repressing Integrin/FAK/PI3K/Akt Pathway in Hepatic Stellate Cells.
Molecules
; 24(20)2019 Oct 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-31627430
17.
Evolution and Biological Evaluation of Matrinic Derivatives with Amantadine Fragments As New Anti-Influenza Virus Agents.
Molecules
; 24(5)2019 Mar 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30845734
18.
Evolution and Antibacterial Evaluation of 8-Hydroxy-cycloberberine Derivatives as a Novel Family of Antibacterial Agents Against MRSA.
Molecules
; 24(5)2019 Mar 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30862066
19.
Synthesis and Biological Evaluation of Quinoline Derivatives as a Novel Class of Broad-Spectrum Antibacterial Agents.
Molecules
; 24(3)2019 Feb 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30717338
20.
Construction and synthesis of tricyclic matrinic derivatives against influenza A virus by privileged structure strategy.
Pharmazie
; 74(5): 265-269, 2019 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31109395