Detalles de la búsqueda
1.
Insight into the Therapeutic Potential of a Bicyclic Hydroxypyridone Compound 2-[(2,4-Dichlorophenyl)methyl]-7-hydroxy-1,2,3,4-tetrahydro-8H-pyrido[1,2-a]pyrazin-8-one as COMT Inhibitor in the Treatment of Parkinson's Disease: A Molecular Dynamic Simulation Approach.
Chem Biodivers
; 18(9): e2100204, 2021 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-34252268
2.
Investigating the Mechanistic Inhibitory Discrepancies of Novel Halogen and Alkyl Di-Substituted Oxadiazole-Based Dibenzo-Azepine-Dione Derivatives on Poly (ADP-Ribose) Polymerase-1.
Chem Biodivers
; 18(1): e2000802, 2021 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-33289285
3.
An In Silico Functional Analysis of Non-Synonymous Single-Nucleotide Polymorphisms of Bovine CMAH Gene and Potential Implication in Pathogenesis.
Pathogens
; 12(4)2023 Apr 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37111477
4.
Inherent efficacies of pyrazole-based derivatives for cancer therapy: the interface between experiment and in silico.
Future Med Chem
; 15(18): 1719-1738, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37772542
5.
From a Computational Perspective: Elucidating the Neurotherapeutic and Inhibitory properties of LRRK2 Kinase Domain by a benzothiazole-based compound.
Curr Pharm Biotechnol
; 2022 May 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-35616668
6.
Weak spots inhibition in the Mycobacterium tuberculosis antigen 85C target for antitubercular drug design through selective irreversible covalent inhibitor-SER124.
J Biomol Struct Dyn
; 40(7): 2934-2954, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33155529
7.
Piecing the Fragments Together: Dynamical Insights into the Enhancement of BRD4-BD1 (BET Protein) Druggability in Cancer Chemotherapy Using Novel 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one Derivatives.
Curr Pharm Biotechnol
; 23(3): 444-456, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-33749556
8.
Probing Protein-protein Interactions and Druggable Site Identification: Mechanistic Binding Events Between Ubiquitin and Zinc Finger with UFM1-specific Peptidase Domain Protein (ZUFSP).
Comb Chem High Throughput Screen
; 25(5): 831-837, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-33538664
9.
Uganda Genome Resource: A rich research database for genomic studies of communicable and non-communicable diseases in Africa.
Cell Genom
; 2(11): None, 2022 Nov 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36388767
10.
Transferability of genetic risk scores in African populations.
Nat Med
; 28(6): 1163-1166, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35654908
11.
Update and Potential Opportunities in CBP [Cyclic Adenosine Monophosphate (cAMP) Response Element-Binding Protein (CREB)-Binding Protein] Research Using Computational Techniques.
Protein J
; 40(1): 19-27, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33394237
12.
Atomistic insights into the selective therapeutic activity of 6-(2,4-difluorophenoxy)-5-((ethylmethyl)pyridine-3-yl)-8-methylpyrrolo[1,2-a]pyrazin-1(2H)-one towards bromodomain-containing proteins.
Comput Biol Chem
; 95: 107592, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34710811
13.
East to West not North-West: Structure-Based Mechanistic Resolution of 8-Hydroxyl Replacement and Resulting Effects on the Activities of Imidazole-Based Heme Oxygenase-1 Inhibitors.
Protein J
; 40(2): 166-174, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33646477
14.
Prospecting the therapeutic edge of a novel compound (B12) over berberine in the selective targeting of Retinoid X Receptor in colon cancer.
J Mol Model
; 27(8): 231, 2021 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-34312718
15.
Transcription-translation error: In-silico investigation of the structural and functional impact of deleterious single nucleotide polymorphisms in GULP1 gene.
Inform Med Unlocked
; 222021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33665355
16.
Therapeutic Path to Double Knockout: Investigating the Selective Dual-Inhibitory Mechanisms of Adenosine Receptors A1 and A2 by a Novel Methoxy-Substituted Benzofuran Derivative in the Treatment of Parkinson's Disease.
Cell Biochem Biophys
; 79(1): 25-36, 2021 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-33222095
17.
Structural alterations in the catalytic core of hSIRT2 enzyme predict therapeutic benefits of Garcinia mangostana derivatives in Alzheimer's disease: molecular dynamics simulation study.
RSC Adv
; 11(14): 8003-8018, 2021 Feb 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-35423339
18.
Functional Analysis of Single Nucleotide Polymorphism in ZUFSP Protein and Implication in Pathogenesis.
Protein J
; 40(1): 28-40, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33512633
19.
Leveraging on Active Site Similarities; Identification of Potential Inhibitors of Zinc-Finger and UFSP domain Protein (ZUFSP).
Curr Pharm Biotechnol
; 22(7): 995-1004, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-32744966
20.
Identification and classification of differentially expressed genes reveal potential molecular signature associated with SARS-CoV-2 infection in lung adenocarcinomal cells.
Inform Med Unlocked
; 20: 100384, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32835074