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1.
Preclinical Characterization of AZD9574, a Blood-Brain Barrier Penetrant Inhibitor of PARP1.
Clin Cancer Res
; 30(7): 1338-1351, 2024 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37967136
2.
The PARP1 Inhibitor AZD5305 Impairs Ovarian Adenocarcinoma Progression and Visceral Metastases in Patient-derived Xenografts Alone and in Combination with Carboplatin.
Cancer Res Commun
; 3(3): 489-500, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36994441
3.
Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305.
Clin Cancer Res
; 29(6): 1086-1101, 2023 03 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36355054
4.
PARP inhibition is a modulator of anti-tumor immune response in BRCA-deficient tumors.
Oncoimmunology
; 11(1): 2083755, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35756843
5.
Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper.
Clin Cancer Res
; 28(21): 4724-4736, 2022 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35929986
6.
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.
J Med Chem
; 64(19): 14498-14512, 2021 10 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-34570508
7.
Longitudinal immune characterization of syngeneic tumor models to enable model selection for immune oncology drug discovery.
J Immunother Cancer
; 7(1): 328, 2019 11 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-31779705
8.
Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor-positive Breast Cancer.
Mol Cancer Ther
; 17(5): 908-920, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29483206
9.
Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions.
Mol Cancer Ther
; 17(5): 885-896, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29483211
10.
Stat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors.
PLoS One
; 7(12): e52608, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-23285109
11.
Stat3 controls lysosomal-mediated cell death in vivo.
Nat Cell Biol
; 13(3): 303-9, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21336304
12.
CD70-driven chronic immune activation is protective against atherosclerosis.
J Innate Immun
; 2(4): 344-52, 2010.
Artículo
en Inglés
| MEDLINE | ID: mdl-20505312
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