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1.
Novel SPME fibers based on a plastic support for determination of plasma protein binding of thiosemicarbazone metal chelators: a case example of DpC, an anti-cancer drug that entered clinical trials.
Anal Bioanal Chem
; 411(11): 2383-2394, 2019 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-30820631
2.
Pharmacokinetics of the Cardioprotective Drug Dexrazoxane and Its Active Metabolite ADR-925 with Focus on Cardiomyocytes and the Heart.
J Pharmacol Exp Ther
; 364(3): 433-446, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29273587
3.
Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: application to a pilot pharmacokinetic study in rats.
Biomed Chromatogr
; 28(5): 621-9, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24254882
4.
Identification of in vitro metabolites of the novel anti-tumor thiosemicarbazone, DpC, using ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry.
Anal Bioanal Chem
; 405(5): 1651-61, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23180090
5.
LC-MS/MS identification of the principal in vitro and in vivo phase I metabolites of the novel thiosemicarbazone anti-cancer drug, Bp4eT.
Anal Bioanal Chem
; 403(1): 309-21, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-22349326
6.
Synthesis and initial in vitro evaluations of novel antioxidant aroylhydrazone iron chelators with increased stability against plasma hydrolysis.
Chem Res Toxicol
; 24(3): 290-302, 2011 Mar 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-21214215
7.
Use of different stationary phases for separation of isoniazid, its metabolites and vitamin B6 forms.
J Sep Sci
; 34(12): 1357-65, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21567949
8.
Development of an LC-MS/MS method for analysis of interconvertible Z/E isomers of the novel anticancer agent, Bp4eT.
Anal Bioanal Chem
; 397(1): 161-171, 2010 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20127082
9.
HPLC methods for determination of two novel thiosemicarbazone anti-cancer drugs (N4mT and Dp44mT) in plasma and their application to in vitro plasma stability of these agents.
J Chromatogr B Analyt Technol Biomed Life Sci
; 877(3): 316-22, 2009 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19097949
10.
LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH).
J Pharm Biomed Anal
; 105: 55-63, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25527982
11.
Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents.
Oncotarget
; 6(40): 42411-28, 2015 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26623727
12.
In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites.
PLoS One
; 10(10): e0139929, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26460540
13.
Development of LC-MS/MS method for the simultaneous analysis of the cardioprotective drug dexrazoxane and its metabolite ADR-925 in isolated cardiomyocytes and cell culture medium.
J Pharm Biomed Anal
; 76: 243-51, 2013 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-23339990
14.
Hydrophilic interaction liquid chromatography in the separation of a moderately lipophilic drug from its highly polar metabolites--the cardioprotectant dexrazoxane as a model case.
J Chromatogr A
; 1218(3): 416-26, 2011 Jan 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-21168142
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