Detalles de la búsqueda
1.
A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.
Nucleic Acids Res
; 46(8): 4114-4128, 2018 05 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29538767
2.
Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase.
Proc Natl Acad Sci U S A
; 114(22): E4492-E4500, 2017 05 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-28507124
3.
Structure-guided design of antibacterials that allosterically inhibit DNA gyrase.
Bioorg Med Chem Lett
; 29(11): 1407-1412, 2019 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30962087
4.
A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.
Nucleic Acids Res
; 46(8): 4325, 2018 05 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29596599
5.
Cocktailed fragment screening by X-ray crystallography of the antibacterial target undecaprenyl pyrophosphate synthase from Acinetobacter baumannii.
Acta Crystallogr F Struct Biol Commun
; 76(Pt 1): 40-46, 2020 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31929185
6.
Mechanistic aspects of maltotriose-conjugate translocation to the Gram-negative bacteria cytoplasm.
Life Sci Alliance
; 2(1): e201800242, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30620010
7.
Getting Drugs into Gram-Negative Bacteria: Rational Rules for Permeation through General Porins.
ACS Infect Dis
; 4(10): 1487-1498, 2018 10 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29962203
8.
Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones.
J Med Chem
; 61(8): 3565-3581, 2018 04 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29596745
9.
Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors.
J Med Chem
; 50(1): 6-9, 2007 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-17201405
10.
Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity.
J Med Chem
; 50(1): 2-5, 2007 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-17201404
11.
Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase.
J Med Chem
; 59(15): 7299-304, 2016 Aug 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27379833
12.
Microspectrometric insights on the uptake of antibiotics at the single bacterial cell level.
Sci Rep
; 5: 17968, 2015 Dec 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-26656111
13.
Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.
Nat Commun
; 6: 10048, 2015 Dec 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26640131
14.
Cyclopropanation with Diazomethane and Bis(oxazoline)palladium(II) Complexes.
J Org Chem
; 62(10): 3375-3389, 1997 May 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-11671727
15.
Enantioselective Ring Opening of Epoxides with Silicon Tetrachloride in the Presence of a Chiral Lewis Base.
J Org Chem
; 63(8): 2428-2429, 1998 Apr 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-11672098
16.
Asymmetric Catalysis in Diversity-Oriented Organic Synthesis: Enantioselective Synthesis of 4320 Encoded and Spatially Segregated Dihydropyrancarboxamides We thank the National Institute of General Medical Sciences (GM-52067) for support of this research, and Dr. John Tallarico and Max Narovlyansky at the ICCB for generously providing resin for the library synthesis. We thank Dr. Helen Blackwell and Lucy Pérez for expert help with library encoding. We are grateful to Prof. Eric Jacobsen and Prof. Scott Denmark for the use of their chiral stationary phase high pressure liquid chromatograph and supercritical fluid chromatograph, respectively. The Harvard ICCB is supported by Merck & Co., Merck KGaA, the Keck Foundation, and the National Cancer Institute. R.A.S. is a Research Associate and S.L.S. is an Investigator with the Howard Hughes Medical Institute at the Department of Chemistry and Chemical Biology, Harvard University.
Angew Chem Int Ed Engl
; 40(18): 3417-3421, 2001 Sep 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-11592157
17.
TRANSLOCATION project: how to get good drugs into bad bugs.
Sci Transl Med
; 6(228): 228ed7, 2014 Mar 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-24648337
18.
Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities.
J Pharmacol Exp Ther
; 320(1): 89-98, 2007 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-17018693
19.
Chiral phosphoramide-catalyzed aldol additions of ketone trichlorosilyl enolates. Mechanistic aspects.
J Org Chem
; 71(10): 3904-22, 2006 May 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-16674067
Resultados
1 -
19
de 19
1
Próxima >
>>