Detalles de la búsqueda
1.
Automated Affinity Capture and On-Tip Digestion to Accurately Quantitate in Vivo Deamidation of Therapeutic Antibodies.
Anal Chem
; 88(23): 11521-11526, 2016 12 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27797494
2.
Development of a human IgG4 bispecific antibody for dual targeting of interleukin-4 (IL-4) and interleukin-13 (IL-13) cytokines.
J Biol Chem
; 288(37): 26583-93, 2013 Sep 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-23880771
3.
Sialic Acid Mediated Endothelial and Hepatic Uptake: A Mechanism based Mathematic Model Elucidating the Complex Pharmacokinetics and Pharmacodynamics of Efmarodocokin Alfa, a Variably Glycosylated Fusion Protein.
J Pharm Sci
; 2024 Mar 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-38561054
4.
Mini-PBPK-Based Population Model and Covariate Analysis to Assess the Complex Pharmacokinetics and Pharmacodynamics of RO7449135, an Anti-KLK5/KLK7 Bispecific Antibody in Cynomolgus Monkeys.
AAPS J
; 25(4): 64, 2023 06 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-37353723
5.
Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFß3 Antibody for the Treatment of Fibrotic Diseases.
J Pharm Sci
; 112(11): 2910-2920, 2023 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-37429356
6.
Nonclinical Pharmacokinetics and Pharmacodynamics Characterization of Anti-CD79b/CD3 T Cell-Dependent Bispecific Antibody Using a Surrogate Molecule: A Potential Therapeutic Agent for B Cell Malignancies.
Pharmaceutics
; 14(5)2022 Apr 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-35631556
7.
First-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors.
Clin Cancer Res
; 28(16): 3452-3463, 2022 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35699599
8.
An integrated approach for characterizing immunogenic responses toward a bispecific antibody.
MAbs
; 13(1): 1944017, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34225571
9.
Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling.
NPJ Syst Biol Appl
; 6(1): 28, 2020 08 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-32859946
10.
Randomized Phase I Healthy Volunteer Study of UTTR1147A (IL-22Fc): A Potential Therapy for Epithelial Injury.
Clin Pharmacol Ther
; 105(1): 177-189, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29952004
11.
Evidence for an asialoglycoprotein receptor on nonparenchymal cells for O-linked glycoproteins.
J Pharmacol Exp Ther
; 327(2): 308-15, 2008 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-18728239
12.
A Preclinical Population Pharmacokinetic Model for Anti-CD20/CD3 T-Cell-Dependent Bispecific Antibodies.
Clin Transl Sci
; 11(3): 296-304, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29351372
13.
Pre-clinical and translational pharmacology of a human interleukin-22 IgG fusion protein for potential treatment of infectious or inflammatory diseases.
Biochem Pharmacol
; 152: 224-235, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29608910
14.
Nonclinical safety assessment of a human interleukin-22FC IG fusion protein demonstrates in vitro to in vivo and cross-species translatability.
Pharmacol Res Perspect
; 6(6): e00434, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30464842
15.
Preclinical pharmacokinetic characterization of an adipose tissue-targeting monoclonal antibody in obese and non-obese animals.
MAbs
; 9(8): 1379-1388, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28895785
16.
Therapeutic Antibody-Induced Vascular Toxicity Due to Off-Target Activation of Nitric Oxide in Cynomolgus Monkeys.
Toxicol Sci
; 151(2): 245-60, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-26917699
17.
Anti-CD20/CD3 T cell-dependent bispecific antibody for the treatment of B cell malignancies.
Sci Transl Med
; 7(287): 287ra70, 2015 May 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-25972002
18.
Antitumor efficacy of a bispecific antibody that targets HER2 and activates T cells.
Cancer Res
; 74(19): 5561-71, 2014 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25228655
19.
Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.
PLoS One
; 8(12): e83958, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24409221
20.
Production, characterization, and pharmacokinetic properties of antibodies with N-linked mannose-5 glycans.
MAbs
; 4(4): 475-87, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22699308