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1.
Difluoromethyl-1,3,4-oxadiazoles are slow-binding substrate analog inhibitors of histone deacetylase 6 with unprecedented isotype selectivity.
J Biol Chem
; 299(1): 102800, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36528061
2.
Mechanistic and Structural Insights on Difluoromethyl-1,3,4-oxadiazole Inhibitors of HDAC6.
Int J Mol Sci
; 25(11)2024 May 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-38892072
3.
The Novel SSTR3 Agonist ITF2984 Exerts Antimitotic and Proapoptotic Effects in Human Non-Functioning Pituitary Neuroendocrine Tumor (NF-PitNET) Cells.
Int J Mol Sci
; 25(7)2024 Mar 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38612419
4.
Characterization of the Cardiac Structure and Function of Conscious D2.B10-Dmdmdx/J (D2-mdx) mice from 16-17 to 24-25 Weeks of Age.
Int J Mol Sci
; 24(14)2023 Jul 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-37511564
5.
HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling.
Circulation
; 143(19): 1874-1890, 2021 05 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33682427
6.
Improved In Vivo Anti-Tumor and Anti-Metastatic Effect of GnRH-III-Daunorubicin Analogs on Colorectal and Breast Carcinoma Bearing Mice.
Int J Mol Sci
; 20(19)2019 Sep 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-31557968
7.
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients.
Trends Mol Med
; 30(3): 278-294, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38408879
8.
Uracil- and Pyridine-Containing HDAC Inhibitors Displayed Cytotoxicity in Colorectal and Glioblastoma Cancer Stem Cells.
ChemMedChem
; : e202300655, 2024 Mar 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-38529661
9.
Translation of paclitaxel-induced peripheral neurotoxicity from mice to patients: the importance of model selection.
Pain
; 2024 May 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38723182
10.
Skin equivalents: a tool for the discovery and validation of pharmacodynamic biomarkers.
Cancer Invest
; 31(1): 60-6, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23327193
11.
The Importance of the "Time Factor" for the Evaluation of Inhibition Mechanisms: The Case of Selected HDAC6 Inhibitors.
Biology (Basel)
; 12(8)2023 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-37626935
12.
LKB1 signaling is altered in skeletal muscle of a Duchenne muscular dystrophy mouse model.
Dis Model Mech
; 16(7)2023 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37427454
13.
Identification of a Novel SSTR3 Full Agonist for the Treatment of Nonfunctioning Pituitary Adenomas.
Cancers (Basel)
; 15(13)2023 Jun 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-37444563
14.
Inhibition of the lysine demethylase LSD1 modulates the balance between inflammatory and antiviral responses against coronaviruses.
Sci Signal
; 16(816): eade0326, 2023 12 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-38113337
15.
HDAC Inhibition as Potential Therapeutic Strategy to Restore the Deregulated Immune Response in Severe COVID-19.
Front Immunol
; 13: 841716, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35592335
16.
Givinostat-Liposomes: Anti-Tumor Effect on 2D and 3D Glioblastoma Models and Pharmacokinetics.
Cancers (Basel)
; 14(12)2022 Jun 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-35740641
17.
Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 1.
Bioorg Med Chem Lett
; 21(15): 4422-8, 2011 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21737272
18.
N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists.
Bioorg Med Chem Lett
; 21(18): 5283-8, 2011 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21802943
19.
Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors.
Bioorg Med Chem Lett
; 21(18): 5274-82, 2011 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21803580
20.
Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 2.
Bioorg Med Chem Lett
; 21(15): 4429-35, 2011 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21737263