Detalles de la búsqueda
1.
Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds-synthesis, biological activity, and structural evaluation.
J Enzyme Inhib Med Chem
; 38(1): 2209828, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37184096
2.
Development and Characterization of Novel Selective, Non-Basic Dopamine D2 Receptor Antagonists for the Treatment of Schizophrenia.
Molecules
; 28(10)2023 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-37241951
3.
Screening and Structure-Activity Relationship of D2AAK1 Derivatives for Potential Application in the Treatment of Neurodegenerative Diseases.
Molecules
; 27(7)2022 Mar 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-35408637
4.
Overcoming Depression with 5-HT2A Receptor Ligands.
Int J Mol Sci
; 23(1)2021 Dec 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-35008436
5.
The Antipsychotic D2AAK1 as a Memory Enhancer for Treatment of Mental and Neurodegenerative Diseases.
Int J Mol Sci
; 21(22)2020 Nov 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-33238370
6.
Multi-Target Approach for Drug Discovery against Schizophrenia.
Int J Mol Sci
; 19(10)2018 Oct 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30309037
7.
Current Concepts and Treatments of Schizophrenia.
Molecules
; 23(8)2018 Aug 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-30127324
8.
Discovery and inâ vitro Evaluation of Novel Serotonin 5-HT2A Receptor Ligands Identified Through Virtual Screening.
ChemMedChem
; : e202400080, 2024 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38619283
9.
Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents - Design, synthesis, structural studies and pharmacological profiling.
Eur J Med Chem
; 252: 115285, 2023 Apr 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37027998
10.
What are the challenges with multi-targeted drug design for complex diseases?
Expert Opin Drug Discov
; 17(7): 673-683, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35549603
11.
Multitarget Derivatives of D2AAK1 as Potential Antipsychotics: The Effect of Substitution in the Indole Moiety.
ChemMedChem
; 17(15): e202200238, 2022 08 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35610178
12.
Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like processes.
Sci Rep
; 12(1): 21192, 2022 12 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36476619
13.
Multi-targeted drug design strategies for the treatment of schizophrenia.
Expert Opin Drug Discov
; 16(1): 101-114, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32915109
14.
Current Approaches and Tools Used in Drug Development against Parkinson's Disease.
Biomolecules
; 11(6)2021 06 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-34208760
15.
N-(3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}propyl)-1H-indazole-3-carboxamide (D2AAK3) as a potential antipsychotic: In vitro, in silico and in vivo evaluation of a multi-target ligand.
Neurochem Int
; 146: 105016, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33722679
17.
Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs.
Eur J Med Chem
; 180: 673-689, 2019 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31357129
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