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1.
Continuous low-dose infusion of patupilone increases the therapeutic index in mouse and rat tumour models.
Anticancer Drugs
; 29(7): 691-701, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29734209
2.
Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers.
Nat Cancer
; 2024 Apr 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38565920
3.
Transient Inhibition of the JAK/STAT Pathway Prevents B-ALL Development in Genetically Predisposed Mice.
Cancer Res
; 82(6): 1098-1109, 2022 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35131871
4.
A Microphysiological Cell-Culturing System for Pharmacokinetic Drug Exposure and High-Resolution Imaging of Arrays of 3D Microtissues.
Front Pharmacol
; 12: 785851, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-35342386
5.
Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4.
J Med Chem
; 63(21): 12542-12573, 2020 11 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32930584
6.
FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer.
Mol Cancer Ther
; 18(12): 2194-2206, 2019 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31409633
7.
Author Correction: Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers.
Nat Cancer
; 2024 Jun 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38886525
8.
Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201.
Cancer Res
; 78(21): 6257-6267, 2018 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30135191
9.
Continuous low plasma concentrations of everolimus provides equivalent efficacy to oral daily dosing in mouse xenograft models of human cancer.
Cancer Chemother Pharmacol
; 80(4): 869-878, 2017 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-28779265
10.
Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia.
Cancer Cell
; 28(1): 29-41, 2015 Jul 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-26175414
11.
JAK1/2 and Pan-deacetylase inhibitor combination therapy yields improved efficacy in preclinical mouse models of JAK2V617F-driven disease.
Clin Cancer Res
; 19(22): 6230-41, 2013 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24081976
12.
K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo.
PLoS One
; 7(8): e44146, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22952903
13.
Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor.
Mol Cancer Ther
; 11(2): 317-28, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22188813
14.
Characterization of the mechanism of action of the pan class I PI3K inhibitor NVP-BKM120 across a broad range of concentrations.
Mol Cancer Ther
; 11(8): 1747-57, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22653967
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