Detalles de la búsqueda
1.
Ligand structures of synthetic deoxa-pyranosylamines with raucaffricine and strictosidine glucosidases provide structural insights into their binding and inhibitory behaviours.
J Enzyme Inhib Med Chem
; 30(3): 472-8, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25140865
2.
Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding.
J Biol Chem
; 287(14): 11213-21, 2012 Mar 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-22334702
3.
Scaffold tailoring by a newly detected Pictet-Spenglerase activity of strictosidine synthase: from the common tryptoline skeleton to the rare piperazino-indole framework.
J Am Chem Soc
; 134(3): 1498-500, 2012 Jan 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-22229634
4.
The Pictet-Spengler reaction in nature and in organic chemistry.
Angew Chem Int Ed Engl
; 50(37): 8538-64, 2011 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-21830283
5.
Enzymatic and chemo-enzymatic approaches towards natural and non-natural alkaloids: indoles, isoquinolines, and others.
Top Curr Chem
; 297: 67-103, 2010.
Artículo
en Inglés
| MEDLINE | ID: mdl-21495257
6.
Synthesis, biological evaluation, and structure-activity relationship study of novel cytotoxic aza-caffeic acid derivatives.
Bioorg Med Chem
; 18(17): 6351-9, 2010 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20673727
7.
Improved expression of His(6)-tagged strictosidine synthase cDNA for chemo-enzymatic alkaloid diversification.
Chem Biodivers
; 7(4): 860-70, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-20397221
8.
Preparation of two sets of 5,6,7-trioxygenated dihydroflavonol derivatives as free radical scavengers and neuronal cell protectors to oxidative damage.
Bioorg Med Chem
; 17(9): 3414-25, 2009 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19362850
9.
Preparation of C-23 esterified silybin derivatives and evaluation of their lipid peroxidation inhibitory and DNA protective properties.
Bioorg Med Chem
; 17(17): 6380-9, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19660956
10.
Antioxidant and neuroprotective effects of synthesized sintenin derivatives.
J Enzyme Inhib Med Chem
; 24(2): 425-31, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-18825550
11.
Phytochemical investigation and cytotoxic evaluation of the components of the medicinal plant Ligularia atroviolacea.
Chem Biodivers
; 6(7): 1053-65, 2009 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-19623551
12.
Structural basis and enzymatic mechanism of the biosynthesis of C9- from C10-monoterpenoid indole alkaloids.
Angew Chem Int Ed Engl
; 48(28): 5211-3, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19496101
13.
Strictosidine synthase: mechanism of a Pictet-Spengler catalyzing enzyme.
J Am Chem Soc
; 130(2): 710-23, 2008 Jan 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-18081287
14.
Structure-based engineering of strictosidine synthase: auxiliary for alkaloid libraries.
Chem Biol
; 14(9): 979-85, 2007 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-17884630
15.
3D-Structure and function of strictosidine synthase--the key enzyme of monoterpenoid indole alkaloid biosynthesis.
Plant Physiol Biochem
; 46(3): 340-55, 2008 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-18280746
16.
A new dibenzofuran and other constituents from Ligularia caloxantha, a Chinese medicinal plant.
Nat Prod Res
; 22(7): 628-32, 2008 May 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-18569702
17.
Preparation of ferulic acid derivatives and evaluation of their xanthine oxidase inhibition activity.
Nat Prod Res
; 21(3): 196-202, 2007 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-17365708
18.
Expression, purification, crystallization and preliminary X-ray analysis of strictosidine glucosidase, an enzyme initiating biosynthetic pathways to a unique diversity of indole alkaloid skeletons.
Biochim Biophys Acta
; 1747(1): 89-92, 2005 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-15680242
19.
Heterologous expression, purification, crystallization and preliminary X-ray analysis of raucaffricine glucosidase, a plant enzyme specifically involved in Rauvolfia alkaloid biosynthesis.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 62(Pt 3): 257-60, 2006 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16511316
20.
Expression, purification, crystallization and preliminary X-ray analysis of perakine reductase, a new member of the aldo-keto reductase enzyme superfamily from higher plants.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 62(Pt 12): 1286-9, 2006 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17142919