Detalles de la búsqueda
1.
Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models.
Proc Natl Acad Sci U S A
; 120(1): e2211297120, 2023 01 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36574664
2.
Optimization of ether and aniline based inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett
; 41: 127974, 2021 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33771585
3.
Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hürthle Cell Carcinoma of the Thyroid.
Cancer Discov
; 13(8): 1884-1903, 2023 08 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-37262072
4.
Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors.
J Med Chem
; 66(24): 16783-16806, 2023 12 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-38085679
5.
Optimization of 1,2,4-Triazole-Based p97 Inhibitors for the Treatment of Cancer.
ACS Med Chem Lett
; 14(7): 977-985, 2023 Jul 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37465292
6.
Sulforaphane is Synergistic with CB-5083 and Inhibits Colony Formation of CB-5083-Resistant HCT116 Cells.
ChemMedChem
; 17(11): e202200030, 2022 06 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35451199
7.
Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization.
J Med Chem
; 65(8): 6287-6312, 2022 04 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-35436124
8.
Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs.
Mol Cancer Ther
; 21(10): 1510-1523, 2022 10 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35876604
9.
Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer.
J Med Chem
; 64(8): 4913-4946, 2021 04 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-33822623
10.
Allosteric p97 Inhibitors Can Overcome Resistance to ATP-Competitive p97 Inhibitors for Potential Anticancer Therapy.
ChemMedChem
; 15(8): 685-694, 2020 04 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-32162487
11.
Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.
J Med Chem
; 63(2): 656-675, 2020 01 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-31858797
12.
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.
J Med Chem
; 63(19): 10984-11011, 2020 10 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32902275
13.
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.
Cell Rep
; 30(6): 1798-1810.e4, 2020 02 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32049011
14.
Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma.
Cancer Res
; 79(19): 5060-5073, 2019 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31431459
15.
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
J Med Chem
; 60(22): 9184-9204, 2017 11 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-29120638
Resultados
1 -
15
de 15
1
Próxima >
>>