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1.
Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints.
Bioorg Med Chem
; 28(1): 115194, 2020 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31786008
2.
The potent BACE1 inhibitor LY2886721 elicits robust central Aß pharmacodynamic responses in mice, dogs, and humans.
J Neurosci
; 35(3): 1199-210, 2015 Jan 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-25609634
3.
Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design.
Bioorg Med Chem Lett
; 26(14): 3274-3277, 2016 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27261179
4.
Preparation and biological evaluation of conformationally constrained BACE1 inhibitors.
Bioorg Med Chem
; 23(13): 3260-8, 2015 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26001341
5.
ESR and X-ray Structure Investigations on the Binding and Mechanism of Inhibition of the Native State of Myeloperoxidase with Low Molecular Weight Fragments.
Appl Magn Reson
; 46(8): 853-873, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26224994
6.
LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models.
Invest New Drugs
; 31(4): 833-44, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23275061
7.
Robust central reduction of amyloid-ß in humans with an orally available, non-peptidic ß-secretase inhibitor.
J Neurosci
; 31(46): 16507-16, 2011 Nov 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-22090477
8.
Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt).
J Med Chem
; 64(9): 5470-5484, 2021 05 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-33852312
9.
Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor.
J Med Chem
; 64(12): 8076-8100, 2021 06 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34081466
10.
Merestinib (LY2801653) inhibits neurotrophic receptor kinase (NTRK) and suppresses growth of NTRK fusion bearing tumors.
Oncotarget
; 9(17): 13796-13806, 2018 Mar 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29568395
11.
Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
J Med Chem
; 57(24): 10476-85, 2014 Dec 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25415648
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